Long Non-coding RNA PVT1 Interacts with MYC and Its Downstream Molecules to Synergistically Promote Tumorigenesis

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2019 Jul 17

PMID 31309249

Citations 83

Authors

Ke Jin

Shufei Wang

Yazhuo Zhang

Mengfang Xia

Yongzhen Mo

Xiaoling Li

Guiyuan Li

Zhaoyang Zeng

Wei Xiong

Yi He

Affiliations

Soon will be listed here.

Abstract

Numerous studies have shown that non-coding RNAs play crucial roles in the development and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly encodes a long non-coding RNA (lncRNA) and is located on chromosome 8q24.21, which constitutes a fragile site for genetic aberrations. PVT1 is well-known for its interaction with its neighbor MYC, which is a qualified oncogene that plays a vital role in tumorigenesis. In the past several decades, increasing attention has been paid to the interaction mechanism between PVT1 and MYC, which will benefit the clinical treatment and prognosis of patients. In this review, we summarize the coamplification of PVT1 and MYC in cancer, the positive feedback mechanism, and the latest promoter competition mechanism of PVT1 and MYC, as well as how PVT1 participates in the downstream signaling pathway of c-Myc by regulating key molecules. We also briefly describe the treatment prospects and research directions of PVT1 and MYC.

Citing Articles

NBAT1/miR-21 axis in progression of colorectal cancer and impact of PVT-1 polymorphism on miR-145 expression level and its clinical significance.

Ayeldeen G, Zaki A, Amer E, Abdellatif Z, Shaker O, Said M Contemp Oncol (Pozn). 2025; 28(4):304-317.

PMID: 39935754 PMC: 11809565. DOI: 10.5114/wo.2024.146961.

The role of curcumin in modulating circular RNAs and long non-coding RNAs in cancer.

Rismanchi H, Malek Mohammadi M, Mafi A, Khalilzadeh P, Farahani N, Mirzaei S Clin Transl Oncol. 2024; .

PMID: 39623194 DOI: 10.1007/s12094-024-03782-0.

Transcriptome-Wide Profiling of Nascent RNA in Neurons with Enriched H3K27ac Signal Elevates eRNA Identification Efficiency.

Jiang J, Liu S, Xu Z, Yu S, Wang L, Long S ACS Chem Neurosci. 2024; .

PMID: 39377285 PMC: 11487572. DOI: 10.1021/acschemneuro.4c00047.

Prediction of the 3D cancer genome from whole-genome sequencing using InfoHiC.

Lee Y, Park S, Lee H Mol Syst Biol. 2024; 20(11):1156-1172.

PMID: 39322849 PMC: 11535030. DOI: 10.1038/s44320-024-00065-2.

Positioning in 8q24.21 Involved in the Tumorigenesis of Colorectal Cancer by Targeting .

Tian S, Chen M, Jing W, Meng Q, Wu J Protein Pept Lett. 2024; 31(7):544-558.

PMID: 39082173 DOI: 10.2174/0109298665305114240718072029.

References

Nakamura Y, Kayano H, Kakegawa E, Miyazaki H, Nagai T, Uchida Y . Identification of SUPT3H as a novel 8q24/MYC partner in blastic plasmacytoid dendritic cell neoplasm with t(6;8)(p21;q24) translocation. Blood Cancer J. 2015; 5:e301. PMC: 4450326. DOI: 10.1038/bcj.2015.26. View

Wong P, Miranda F, Chan K, Berlato C, Hurst H, Scibetta A . Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A). Mol Cell Biol. 2012; 32(9):1633-44. PMC: 3347242. DOI: 10.1128/MCB.06373-11. View

Wei F, Jing Y, He Y, Tang Y, Yang L, Wu Y . Cloning and characterization of the putative AFAP1-AS1 promoter region. J Cancer. 2019; 10(5):1145-1153. PMC: 6400686. DOI: 10.7150/jca.29049. View

Okuda T, Taki T, Nishida K, Chinen Y, Nagoshi H, Sakakura C . Molecular heterogeneity in the novel fusion gene : Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26. Oncol Lett. 2017; 13(1):215-221. PMC: 5244987. DOI: 10.3892/ol.2016.5386. View

Cui M, You L, Ren X, Zhao W, Liao Q, Zhao Y . Long non-coding RNA PVT1 and cancer. Biochem Biophys Res Commun. 2016; 471(1):10-4. DOI: 10.1016/j.bbrc.2015.12.101. View

Xiao L, Wei F, Liang F, Li Q, Deng H, Tan S . TSC22D2 identified as a candidate susceptibility gene of multi-cancer pedigree using genome-wide linkage analysis and whole-exome sequencing. Carcinogenesis. 2019; 40(7):819-827. DOI: 10.1093/carcin/bgz095. View

Tu C, Zeng Z, Qi P, Li X, Guo C, Xiong F . Identification of genomic alterations in nasopharyngeal carcinoma and nasopharyngeal carcinoma-derived Epstein-Barr virus by whole-genome sequencing. Carcinogenesis. 2018; 39(12):1517-1528. DOI: 10.1093/carcin/bgy108. View

Fu C, Li D, Zhang X, Liu N, Chi G, Jin X . LncRNA PVT1 Facilitates Tumorigenesis and Progression of Glioma via Regulation of MiR-128-3p/GREM1 Axis and BMP Signaling Pathway. Neurotherapeutics. 2018; 15(4):1139-1157. PMC: 6277294. DOI: 10.1007/s13311-018-0649-9. View

Wolpin B, Rizzato C, Kraft P, Kooperberg C, Petersen G, Wang Z . Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nat Genet. 2014; 46(9):994-1000. PMC: 4191666. DOI: 10.1038/ng.3052. View

10.

Kim D, Sun M, He L, Zhou Q, Chen J, Sun X . A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem. 2016; 291(43):22856. PMC: 5077231. DOI: 10.1074/jbc.A109.094060. View

11.

Cho K, Cho M, Lee W, Kang K . Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells. Cancer Lett. 2010; 293(2):230-9. DOI: 10.1016/j.canlet.2010.01.013. View

12.

Moschovis D, Vasilaki E, Tzouvala M, Karamanolis G, Katifelis H, Legaki E . Association between genetic polymorphisms in long non-coding RNAs and pancreatic cancer risk. Cancer Biomark. 2018; 24(1):117-123. DOI: 10.3233/CBM-181959. View

13.

Toledo F, Le Roscouet D, Buttin G, Debatisse M . Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification. EMBO J. 1992; 11(7):2665-73. PMC: 556742. DOI: 10.1002/j.1460-2075.1992.tb05332.x. View

14.

Panda A, Grammatikakis I, Kim K, De S, Martindale J, Munk R . Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. Nucleic Acids Res. 2016; 45(7):4021-4035. PMC: 5397146. DOI: 10.1093/nar/gkw1201. View

15.

Bo H, Fan L, Li J, Liu Z, Zhang S, Shi L . High Expression of lncRNA AFAP1-AS1 Promotes the Progression of Colon Cancer and Predicts Poor Prognosis. J Cancer. 2018; 9(24):4677-4683. PMC: 6299385. DOI: 10.7150/jca.26461. View

16.

Wan L, Sun M, Liu G, Wei C, Zhang E, Kong R . Long Noncoding RNA PVT1 Promotes Non-Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression. Mol Cancer Ther. 2016; 15(5):1082-94. DOI: 10.1158/1535-7163.MCT-15-0707. View

17.

Guo J, Hao C, Wang C, Li L . Long noncoding RNA PVT1 modulates hepatocellular carcinoma cell proliferation and apoptosis by recruiting EZH2. Cancer Cell Int. 2018; 18:98. PMC: 6042336. DOI: 10.1186/s12935-018-0582-3. View

18.

Zhang S, Zhang G, Liu J . Long noncoding RNA PVT1 promotes cervical cancer progression through epigenetically silencing miR-200b. APMIS. 2016; 124(8):649-58. DOI: 10.1111/apm.12555. View

19.

Zhou R, Wu Y, Wang W, Su W, Liu Y, Wang Y . Circular RNAs (circRNAs) in cancer. Cancer Lett. 2018; 425:134-142. DOI: 10.1016/j.canlet.2018.03.035. View

20.

Yang Z, Yik J, Chen R, He N, Jang M, Ozato K . Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell. 2005; 19(4):535-45. DOI: 10.1016/j.molcel.2005.06.029. View