Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Aug 31

PMID 30158926

Citations 219

Authors

Veronica Lazar

Lia-Mara Ditu

Gratiela Gradisteanu Pircalabioru

Irina Gheorghe

Carmen Curutiu

Alina Maria Holban

Ariana Picu

Laura Petcu

Mariana Carmen Chifiriuc

Affiliations

Soon will be listed here.

Abstract

The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, bringing to the host organism a dowry of cells and genes more numerous than its own. Among the different non-sterile cavities, the human gut harbors the most complex microbiota, with a strong impact on host homeostasis and immunostasis, being thus essential for maintaining the health condition. In this review, we outline the roles of gut microbiota in immunity, starting with the background information supporting the further presentation of the implications of gut microbiota dysbiosis in host susceptibility to infections, hypersensitivity reactions, autoimmunity, chronic inflammation, and cancer. The role of diet and antibiotics in the occurrence of dysbiosis and its pathological consequences, as well as the potential of probiotics to restore eubiosis is also discussed.

Citing Articles

Causal relationships of gut microbiota and blood metabolites with ovarian cancer and endometrial cancer: a Mendelian randomization study.

Chen J, Chen X, Ma J J Ovarian Res. 2025; 18(1):54.

PMID: 40082983 PMC: 11905533. DOI: 10.1186/s13048-025-01630-5.

Gut microbiota, immune cell, colorectal cancer association mediators: a Mendelian randomization study.

Li Y, Zhuang M, Mei S, Hu G, Zhang J, Qiu W BMC Cancer. 2025; 25(1):396.

PMID: 40038645 PMC: 11881383. DOI: 10.1186/s12885-025-13574-6.

Probiotics and gut microbiota modulation: implications for skin health and disease management.

Parhizkar E, Vosough P, Baneshi M, Keshavarzi A, Lohrasbi P, Taghizadeh S Arch Microbiol. 2025; 207(3):68.

PMID: 39988585 DOI: 10.1007/s00203-025-04267-6.

Microbial effects of cold-pressed Sacha inchi oil supplementation in rats.

Samrit T, Osotprasit S, Chaiwichien A, Suksomboon P, Chansap S, Suthisintong T PLoS One. 2025; 20(2):e0319066.

PMID: 39977445 PMC: 11841868. DOI: 10.1371/journal.pone.0319066.

Noncontact microbiota transplantation by core-shell microgel-enabled nonleakage envelopment.

Wu F, Lin S, Luo H, Wang C, Liu J, Zhu X Sci Adv. 2025; 11(6):eadr7373.

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