Gender Differences in the Interplay Between Vitamin D and Microbiota in Allergic and Autoimmune Diseases

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2024 May 25

PMID 38790985

Authors

Giuseppe Murdaca

Luca Tagliafico

Elena Page

Francesca Paladin

Sebastiano Gangemi

Affiliations

Soon will be listed here.

Abstract

The synergic role of vitamin D and the intestinal microbiota in the regulation of the immune system has been thoroughly described in the literature. Vitamin D deficiency and intestinal dysbiosis have shown a pathogenetic role in the development of numerous immune-mediated and allergic diseases. The physiological processes underlying aging and sex have proven to be capable of having a negative influence both on vitamin D values and the biodiversity of the microbiome. This leads to a global increase in levels of systemic inflammatory markers, with potential implications for all immune-mediated diseases and allergic conditions. Our review aims to collect and analyze the relationship between vitamin D and the intestinal microbiome with the immune system and the diseases associated with it, emphasizing the effect mediated by sexual hormones and aging.

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