Cross Talk from Tubules to Glomeruli

Overview

Journal Toxicol Pathol

Publisher Sage Publications

Date 2018 Aug 31

PMID 30157700

Citations 11

Authors

Jiayi Wang

Jianyong Zhong

Hai-Chun Yang

Agnes B Fogo

Affiliations

Soon will be listed here.

Abstract

Tubular injury sensitizes glomeruli to injury. We review potential mechanisms of this tubuloglomerular cross talk. In the same nephron, tubular injury can cause stenosis of the glomerulotubular junction and finally result in atubular glomeruli. Tubular injury also affects glomerular filtration function through tubuloglomerular feedback. Progenitor cells, that is, parietal epithelial cells and renin positive cells, can be involved in repair of injured glomeruli and also may be modulated by tubular injury. Loss of nephrons induces additional workload and stress on remaining nephrons. Hypoxia and activation of the renin-angiotensin-aldosterone system induced by tubular injury also modulate tubuloglomerular cross talk. Therefore, effective therapies in chronic kidney disease may need to aim to interrupt this deleterious tubuloglomerular cross talk.

Citing Articles

Crosstalk between glomeruli and tubules.

Fogo A, Harris R Nat Rev Nephrol. 2024; 21(3):189-199.

PMID: 39643696 DOI: 10.1038/s41581-024-00907-0.

Adverse effects of acute tubular injury on the glomerulus: contributing factors and mechanisms.

Babickova J, Yang H, Fogo A Pediatr Nephrol. 2024; 39(8):2301-2308.

PMID: 38191938 DOI: 10.1007/s00467-023-06264-7.

Neuroblastoma suppressor of tumorigenicity 1 is associated with the severity of interstitial fibrosis and kidney function decline in IgA nephropathy.

Kobayashi H, Satake E, Murata Y, Otsuka H, Tsunemi A, Azuma M J Nephrol. 2023; 36(8):2245-2256.

PMID: 37436574 DOI: 10.1007/s40620-023-01704-x.

The role of urinary N-acetyl-β-D-glucosaminidase in early detection of acute kidney injury among pediatric patients with neoplastic disorders in a retrospective study.

Biro E, Szegedi I, Kiss C, Olah A, Dockrell M, Price R BMC Pediatr. 2022; 22(1):429.

PMID: 35854249 PMC: 9297588. DOI: 10.1186/s12887-022-03416-w.

Identification and validation of glomerulotubular crosstalk genes mediating IgA nephropathy by integrated bioinformatics.

Bai Y, Li Y, Xi Y, Ma C BMC Nephrol. 2022; 23(1):143.

PMID: 35418061 PMC: 9008921. DOI: 10.1186/s12882-022-02779-7.

References

Allred A, Chappell M, Ferrario C, Diz D . Differential actions of renal ischemic injury on the intrarenal angiotensin system. Am J Physiol Renal Physiol. 2000; 279(4):F636-45. DOI: 10.1152/ajprenal.2000.279.4.F636. View

MAHONEY C, Striker G . Early development of the renal lesions in infantile cystinosis. Pediatr Nephrol. 2000; 15(1-2):50-6. DOI: 10.1007/pl00013448. View

Weichert W, Paliege A, Provoost A, Bachmann S . Upregulation of juxtaglomerular NOS1 and COX-2 precedes glomerulosclerosis in fawn-hooded hypertensive rats. Am J Physiol Renal Physiol. 2001; 280(4):F706-14. DOI: 10.1152/ajprenal.2001.280.4.F706. View

Johnson R, Herrera-Acosta J, Schreiner G, Rodriguez-Iturbe B . Subtle acquired renal injury as a mechanism of salt-sensitive hypertension. N Engl J Med. 2002; 346(12):913-23. DOI: 10.1056/NEJMra011078. View

Tanaka T, Hanafusa N, Ingelfinger J, Ohse T, Fujita T, Nangaku M . Hypoxia induces apoptosis in SV40-immortalized rat proximal tubular cells through the mitochondrial pathways, devoid of HIF1-mediated upregulation of Bax. Biochem Biophys Res Commun. 2003; 309(1):222-31. DOI: 10.1016/s0006-291x(03)01557-2. View

Manotham K, Tanaka T, Matsumoto M, Ohse T, Inagi R, Miyata T . Transdifferentiation of cultured tubular cells induced by hypoxia. Kidney Int. 2004; 65(3):871-80. DOI: 10.1111/j.1523-1755.2004.00461.x. View

Nath K . Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis. 1992; 20(1):1-17. DOI: 10.1016/s0272-6386(12)80312-x. View

Haase V . Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol. 2006; 291(2):F271-81. PMC: 4232221. DOI: 10.1152/ajprenal.00071.2006. View

Najafian B, Crosson J, Kim Y, Mauer M . Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes. J Am Soc Nephrol. 2006; 17(4 Suppl 2):S53-60. DOI: 10.1681/ASN.2005121342. View

10.

Sagrinati C, Netti G, Mazzinghi B, Lazzeri E, Liotta F, Frosali F . Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol. 2006; 17(9):2443-56. DOI: 10.1681/ASN.2006010089. View

11.

Schmidt C, Hocherl K, Schweda F, Kurtz A, Bucher M . Regulation of renal sodium transporters during severe inflammation. J Am Soc Nephrol. 2007; 18(4):1072-83. DOI: 10.1681/ASN.2006050454. View

12.

Kurtz L, Schweda F, De Wit C, Kriz W, Witzgall R, Warth R . Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium. J Am Soc Nephrol. 2007; 18(4):1103-11. DOI: 10.1681/ASN.2006090953. View

13.

Schmidt C, Hocherl K, Schweda F, Bucher M . Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis. Crit Care Med. 2007; 35(9):2110-9. DOI: 10.1097/01.ccm.0000281447.22966.8b. View

14.

White K, Marshall S, Bilous R . Prevalence of atubular glomeruli in type 2 diabetic patients with nephropathy. Nephrol Dial Transplant. 2008; 23(11):3539-45. DOI: 10.1093/ndt/gfn351. View

15.

Araujo M, Welch W . Cyclooxygenase 2 inhibition suppresses tubuloglomerular feedback: roles of thromboxane receptors and nitric oxide. Am J Physiol Renal Physiol. 2009; 296(4):F790-4. PMC: 2670785. DOI: 10.1152/ajprenal.90446.2008. View

16.

Haase V . Pathophysiological Consequences of HIF Activation: HIF as a modulator of fibrosis. Ann N Y Acad Sci. 2009; 1177:57-65. PMC: 4529330. DOI: 10.1111/j.1749-6632.2009.05030.x. View

17.

Singh P, Thomson S . Renal homeostasis and tubuloglomerular feedback. Curr Opin Nephrol Hypertens. 2009; 19(1):59-64. DOI: 10.1097/MNH.0b013e3283331ffd. View

18.

Venkatachalam M, Griffin K, Lan R, Geng H, Saikumar P, Bidani A . Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol. 2010; 298(5):F1078-94. PMC: 2867413. DOI: 10.1152/ajprenal.00017.2010. View

19.

Yang L, Besschetnova T, Brooks C, Shah J, Bonventre J . Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med. 2010; 16(5):535-43, 1p following 143. PMC: 3928013. DOI: 10.1038/nm.2144. View

20.

Siragy H, Carey R . Role of the intrarenal renin-angiotensin-aldosterone system in chronic kidney disease. Am J Nephrol. 2010; 31(6):541-50. PMC: 3202956. DOI: 10.1159/000313363. View