Transfer of Amikacin Resistance by Closely Related Plasmids in Members of the Family Enterobacteriaceae Isolated in Chile

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1986 May 1

PMID 3015007

Citations 10

Authors

G T Van Nhieu

F W Goldstein

M E Pinto

J F Acar

E Collatz

Affiliations

Soon will be listed here.

Abstract

During a 9-month period when amikacin was the sole aminoglycoside used clinically in a hospital in Santiago, Chile, resistance to amikacin and other antibiotics was encountered in 42 strains of the family Enterobacteriaceae, including Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae, Serratia marcescens, and Serratia liquefaciens. Amikacin resistance was transferable by conjugation and carried by IncM plasmids ranging in size from ca. 48.4 to 58.1 kilobase pairs. The plasmids had ca. 70 to 80% of their structure in common, as judged after digestion with restriction endonucleases. The resistance was mediated by a 6' aminoglycoside acetyltransferase. We conclude that selective pressure has favored the dissemination of a wide-host-range amikacin resistance plasmid and its derivatives.

Citing Articles

Amikacin: Uses, Resistance, and Prospects for Inhibition.

Ramirez M, Tolmasky M Molecules. 2017; 22(12).

PMID: 29257114 PMC: 5889950. DOI: 10.3390/molecules22122267.

Heterogeneity of 6'-N-acetyltransferases of type 4 conferring resistance to amikacin and related aminoglycosides in members of the family Enterobacteriaceae.

Tran Van Nhieu G, Collatz E Antimicrob Agents Chemother. 1988; 32(8):1289-91.

PMID: 3056258 PMC: 172397. DOI: 10.1128/AAC.32.8.1289.

Use of plasmid profiles in epidemiologic surveillance of disease outbreaks and in tracing the transmission of antibiotic resistance.

Mayer L Clin Microbiol Rev. 1988; 1(2):228-43.

PMID: 2852997 PMC: 358044. DOI: 10.1128/CMR.1.2.228.

Transposon-mediated amikacin resistance in Klebsiella pneumoniae.

Tolmasky M, Chamorro R, Crosa J, Marini P Antimicrob Agents Chemother. 1988; 32(9):1416-20.

PMID: 2848445 PMC: 175879. DOI: 10.1128/AAC.32.9.1416.

Tn1331, a novel multiresistance transposon encoding resistance to amikacin and ampicillin in Klebsiella pneumoniae.

Tolmasky M, Crosa J Antimicrob Agents Chemother. 1987; 31(12):1955-60.

PMID: 2830842 PMC: 175834. DOI: 10.1128/AAC.31.12.1955.

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