Research Progress on the Relationship Between Atherosclerosis and Inflammation

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2018 Aug 26

PMID 30142970

Citations 311

Authors

Yuhua Zhu

Xuemei Xian

Zhenzhen Wang

Yingchao Bi

Quangang Chen

Xufeng Han

Daoquan Tang

Renjin Chen

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture, vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute cardiovascular disease. Atherosclerosis-related inflammation is mediated by proinflammatory cytokines, inflammatory signaling pathways, bioactive lipids, and adhesion molecules. This review discusses the effects of inflammation and the systemic inflammatory signaling pathway on atherosclerosis, the role of related signaling pathways in inflammation, the formation of atherosclerosis plaques, and the prospects of treating atherosclerosis by inhibiting inflammation.

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