Development and Evaluation of a CEACAM6-targeting Theranostic Nanomedicine for Photoacoustic-based Diagnosis and Chemotherapy of Metastatic Cancer

Overview

Journal Theranostics

Date 2018 Aug 22

PMID 30128051

Citations 12

Authors

Hohyeon Lee

Yongho Jang

Suhyun Park

Hyejin Jang

Eun-Joo Park

Hyun Jung Kim

Hyuncheol Kim

Affiliations

Soon will be listed here.

Abstract

Metastasis is the leading cause of cancer-related deaths. A number of chemotherapeutic and early diagnosis strategies, including nanomedicine, have been developed to target metastatic tumor cells. However, simultaneous inhibition and imaging of metastasis is yet to be fully achieved. To overcome this limitation, we have developed human serum albumin-based nanoparticles (tHSA-NPs) with photoacoustic imaging capability, which target carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6). CEACAM6 is highly expressed in metastatic anoikis-resistant tumor cells. , the CEACAM6-targeting tHSA-NPs efficiently targeted CEACAM6-overexpressing metastatic anoikis-resistant tumor cells. , CEACAM6-targeting tHSA-NPs administered intravenously to BALB/c nude mice efficiently inhibited lung metastasis in circulating anoikis-resistant tumor cells compared to the controls. In addition, anoikis-resistant tumor cells can be successfully detected by photoacoustic imaging, both and using the intrinsic indocyanine green-binding affinity of albumin. In summary, the CEACAM6-targeting albumin-based nanoparticles allowed the delivery of drugs and photoacoustic imaging to metastatic anoikis-resistant tumor cells and . Based on the expression of CEACAM6 in a variety of tumors, CEACAM6-targeting nanomedicine might be used to target various types of metastatic tumor cells.

Citing Articles

CEACAM6 expression and function in tumor biology: a comprehensive review.

Zhao D, Cai F, Liu X, Li T, Zhao E, Wang X Discov Oncol. 2024; 15(1):186.

PMID: 38796667 PMC: 11127906. DOI: 10.1007/s12672-024-01053-6.

New CEACAM-targeting 2A3 single-domain antibody-based chimeric antigen receptor T-cells produce anticancer effects in vitro and in vivo.

Jancewicz I, Smiech M, Winiarska M, Zagozdzon R, Wisniewski P Cancer Immunol Immunother. 2024; 73(2):30.

PMID: 38279989 PMC: 10821984. DOI: 10.1007/s00262-023-03602-4.

The emerging roles of CEACAM6 in human cancer (Review).

Wu G, Wang D, Xiong F, Wang Q, Liu W, Chen J Int J Oncol. 2024; 64(3).

PMID: 38240103 PMC: 10836497. DOI: 10.3892/ijo.2024.5615.

Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies.

Wang J, Luo Z, Lin L, Sui X, Yu L, Xu C Cancers (Basel). 2022; 14(19).

PMID: 36230714 PMC: 9564242. DOI: 10.3390/cancers14194791.

Lipid-Based Nanomaterials for Drug Delivery Systems in Breast Cancer Therapy.

Rethi L, Mutalik C, Anurogo D, Lu L, Chu H, Yougbare S Nanomaterials (Basel). 2022; 12(17).

PMID: 36079985 PMC: 9458017. DOI: 10.3390/nano12172948.

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