CEACAM6 Expression and Function in Tumor Biology: a Comprehensive Review

Overview

Journal Discov Oncol

Publisher Springer

Specialty Oncology

Date 2024 May 25

PMID 38796667

Authors

Dong Zhao

Fei Cai

Xuefei Liu

Tingting Li

Ershu Zhao

Xinlong Wang

Zhendong Zheng

Affiliations

Soon will be listed here.

Abstract

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an immunoglobulin superfamily protein primarily expressed on epithelial surfaces and myeloid cells. It plays a significant role in cancer progression by inhibiting apoptosis, promoting drug resistance, and facilitating cancer cell invasion and metastasis. Overexpression of CEACAM6 has been observed in various cancers, including lung, breast, colorectal, and hepatocellular cancers, and is associated with poorer overall survival and disease-free survival. Its differential expression on tumor cell surfaces makes it a promising cancer marker. This review aims to provide a comprehensive summary of CEACAM6's role in different cancer types, its involvement in signaling pathways, and recent advancements in CEACAM6-targeted treatments.

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