Rheumatic Manifestations of Haemoglobinopathies

Overview

Journal Curr Rheumatol Rep

Publisher Current Science

Specialty Rheumatology

Date 2018 Aug 16

PMID 30109514

Citations 1

Authors

Michael Hughes

Affiliations

Soon will be listed here.

Abstract

Purpose Of The Review: To provide a clinically useful literature review on the rheumatic manifestations of haemoglobinopathies, critically analysing the literature from the past 5 years.

Recent Findings: There are limited new data to guide the management of rheumatic manifestations of haemoglobinopathies. Data further confirm the wide spectrum of potential rheumatic/MSK involvement in haemoglobinopathies, which poses both a diagnostic and therapeutic challenge. Inflammatory arthritis may be more common than previously believed. Steroid therapy by any route of administration can provocate a potential life-threatening vaso-occlusive crisis. Vitamin D deficiency is common. There are limited data to guide the drug treatment of reduced bone density in haemoglobinopathies. There have been a number of studies examining pain in sickle cell anaemia. Plasma levels of Klotho may represent a novel biomarker in patients with β-Thalassemia. There are little new data on the rheumatic manifestations in haemoglobinopathies and future high-quality research is needed.

Citing Articles

Is the treatment of inflammatory arthritis different in sickle cell disease?.

Kimyon G, Ilhan G Turk J Med Sci. 2022; 52(5):1721-1728.

PMID: 36422487 PMC: 10395667. DOI: 10.55730/1300-0144.5515.

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