Musculoskeletal Manifestations of Sickle Cell Anaemia: a Pictorial Review

Overview

Journal Anemia

Publisher Wiley

Date 2011 Apr 15

PMID 21490766

Citations 10

Authors

A Ganguly

W Boswell

H Aniq

Affiliations

Soon will be listed here.

Abstract

Sickle cell anaemia is an autosomal recessive genetic condition producing abnormal haemoglobin HbS molecules that result in stiff and sticky red blood cells leading to unpredictable episodes of microvascular occlusions. The clinical and radiological manifestations of sickle cell anaemia result from small vessel occlusion, leading to tissue ischemia/infarction and progressive end-organ damage. In this paper we discuss and illustrate the various musculoskeletal manifestations of sickle cell disease focusing primarily on marrow hyperplasia, osteomyelitis and septic arthritis, medullary and epiphyseal bone infarcts, growth defects, and soft tissue changes.

Citing Articles

Radiological manifestation of avascular necrosis (AVN) in sickle cell disease (SCD): a review of diagnostic imaging.

Bedair E, Almaslamani N, Yassin M Acta Biomed. 2023; 94(3):e2023177.

PMID: 37326259 PMC: 10308460. DOI: 10.23750/abm.v94i3.14714.

Clinical Vignettes, Part II: Eyes, Teeth, and Bone.

Scott A, Reilly G, Laurence B, Adesina O Hematol Oncol Clin North Am. 2022; 36(6):1201-1215.

PMID: 36400539 PMC: 10204321. DOI: 10.1016/j.hoc.2022.08.010.

Lumbar spine MRI findings in asymptomatic elite male academy footballers: a case series.

Carmody S, Rajeswaran G, Mitchell A, Kryger K, Ahmad I, Gill M BMC Sports Sci Med Rehabil. 2022; 14(1):184.

PMID: 36280886 PMC: 9590204. DOI: 10.1186/s13102-022-00576-1.

Axial Spondyloarthritis: Mimics and Pitfalls of Imaging Assessment.

Proenca Caetano A, Mascarenhas V, Machado P Front Med (Lausanne). 2021; 8:658538.

PMID: 33968964 PMC: 8100693. DOI: 10.3389/fmed.2021.658538.

Rheumatic Manifestations of Haemoglobinopathies.

Hughes M Curr Rheumatol Rep. 2018; 20(10):61.

PMID: 30109514 DOI: 10.1007/s11926-018-0768-7.

References

Burnett M, BASS J, Cook B . Etiology of osteomyelitis complicating sickle cell disease. Pediatrics. 1998; 101(2):296-7. DOI: 10.1542/peds.101.2.296. View

Stark J, Glasier C, Blasier R, Aronson J, Seibert J . Osteomyelitis in children with sickle cell disease: early diagnosis with contrast-enhanced CT. Radiology. 1991; 179(3):731-3. DOI: 10.1148/radiology.179.3.2027983. View

Babhulkar S, Pande K, Babhulkar S . The hand-foot syndrome in sickle-cell haemoglobinopathy. J Bone Joint Surg Br. 1995; 77(2):310-2. View

Almeida A, Roberts I . Bone involvement in sickle cell disease. Br J Haematol. 2005; 129(4):482-90. DOI: 10.1111/j.1365-2141.2005.05476.x. View

Sebes J, DIGGS L . Radiographic changes of the skull in sickle cell anemia. AJR Am J Roentgenol. 1979; 132(3):373-7. DOI: 10.2214/ajr.132.3.373. View

Lonergan G, Cline D, Abbondanzo S . Sickle cell anemia. Radiographics. 2001; 21(4):971-94. DOI: 10.1148/radiographics.21.4.g01jl23971. View

KEELEY K, Buchanan G . Acute infarction of long bones in children with sickle cell anemia. J Pediatr. 1982; 101(2):170-5. DOI: 10.1016/s0022-3476(82)80111-x. View

Datz F, Taylor Jr A . The clinical use of radionuclide bone marrow imaging. Semin Nucl Med. 1985; 15(3):239-59. DOI: 10.1016/s0001-2998(85)80003-9. View

Bahebeck J, Atangana R, Techa A, Monny-Lobe M, Sosso M, Hoffmeyer P . Relative rates and features of musculoskeletal complications in adult sicklers. Acta Orthop Belg. 2004; 70(2):107-11. View

10.

Palestro C, Roumanas P, SWYER A, Kim C, Goldsmith S . Diagnosis of musculoskeletal infection using combined In-111 labeled leukocyte and Tc-99m SC marrow imaging. Clin Nucl Med. 1992; 17(4):269-73. DOI: 10.1097/00003072-199204000-00001. View

11.

Applebaum E, Frankel A . Extramedullary hematopoiesis of the middle ear. Am J Otolaryngol. 1989; 10(4):287-90. DOI: 10.1016/0196-0709(89)90010-0. View

12.

Platt O, Rosenstock W, Espeland M . Influence of sickle hemoglobinopathies on growth and development. N Engl J Med. 1984; 311(1):7-12. DOI: 10.1056/NEJM198407053110102. View

13.

Palestro C, Love C, Tronco G, Tomas M, Rini J . Combined labeled leukocyte and technetium 99m sulfur colloid bone marrow imaging for diagnosing musculoskeletal infection. Radiographics. 2006; 26(3):859-70. DOI: 10.1148/rg.263055139. View

14.

Ware H, Brooks A, Toye R, Berney S . Sickle cell disease and silent avascular necrosis of the hip. J Bone Joint Surg Br. 1991; 73(6):947-9. DOI: 10.1302/0301-620X.73B6.1955442. View

15.

Ejindu V, Hine A, Mashayekhi M, Shorvon P, Misra R . Musculoskeletal manifestations of sickle cell disease. Radiographics. 2007; 27(4):1005-21. DOI: 10.1148/rg.274065142. View

16.

Umans H, Haramati N, Flusser G . The diagnostic role of gadolinium enhanced MRI in distinguishing between acute medullary bone infarct and osteomyelitis. Magn Reson Imaging. 2000; 18(3):255-62. DOI: 10.1016/s0730-725x(99)00137-x. View

17.

Bonnerot V, Sebag G, de Montalembert M, Wioland M, Glorion C, Girot R . Gadolinium-DOTA enhanced MRI of painful osseous crises in children with sickle cell anemia. Pediatr Radiol. 1994; 24(2):92-5. DOI: 10.1007/BF02020160. View

18.

Madani G, Papadopoulou A, Holloway B, Robins A, Davis J, Murray D . The radiological manifestations of sickle cell disease. Clin Radiol. 2007; 62(6):528-38. DOI: 10.1016/j.crad.2007.01.006. View