Antifungal Amphiphilic Kanamycins: New Life for an Old Drug

Overview

Journal Medchemcomm

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Aug 16

PMID 30108980

Citations 9

Authors

Yagya Prasad Subedi

Madher N AlFindee

Jon Y Takemoto

Cheng-Wei Tom Chang

Affiliations

Soon will be listed here.

Abstract

Classical aminoglycoside antibiotics are obsolete or hampered by the emergence of drug resistant bacteria. Recent discoveries of antifungal amphiphilic kanamycins offer new strategies for reviving and repurposing these old drugs. A simple structural modification turns the clinically obsolete antibacterial kanamycin into an antifungal agent. Structure-activity relationship studies have led to the production of , an antifungal kanamycin that can be mass-produced for uses in agriculture as well as in animals. This review delineates the path to the discovery of and other related antifungal amphiphilic kanamycins, determination of its mode of action, and findings in greenhouse and field trials with that could lead to crop disease protection strategies.

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