Aminoglycoside-modifying Enzymes

Overview

Journal Curr Opin Microbiol

Specialty Microbiology

Date 1999 Oct 6

PMID 10508725

Citations 82

Authors

G D Wright

Affiliations

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Abstract

Bacterial resistance to the aminoglycoside antibiotics is most frequently associated with the expression of modifying enzymes that can phosphorylate, adenylate or acetylate these compounds. The recent availability of representative crystal structures for all three classes of modifying enzymes has greatly expanded our knowledge of enzyme function, and has revealed unexpected and exciting connections to other families of enzymes. Furthermore, the complete genome sequences for several bacteria have revealed many potential aminoglycoside-resistance elements.

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