Pigmentation Phototype and Prostate and Breast Cancer in a Select Spanish Population-A Mendelian Randomization Analysis in the MCC-Spain Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Aug 15

PMID 30106959

Citations 3

Authors

Ines Gomez-Acebo

Trinidad Dierssen-Sotos

Camilo Palazuelos

Pablo Fernandez-Navarro

Gemma Castano-Vinyals

Jessica Alonso-Molero

Carmen Urtiaga

Tania Fernandez-Villa

Eva Ardanaz

Manuel Rivas-Del-Fresno

Ana Molina-Barcelo

Jose-Juan Jimenez-Moleon

Lidia Garcia-Martinez

Pilar Amiano

Paz Rodriguez-Cundin

Victor Moreno

Beatriz Perez-Gomez

Nuria Aragones

Manolis Kogevinas

Marina Pollan

Javier Llorca

Affiliations

Soon will be listed here.

Abstract

Introduction: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal.

Methods: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer.

Results: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate.

Conclusions: Phototype is not associated with breast or prostate cancer.

Citing Articles

Skin Phototype and Disease: A Comprehensive Genetic Approach to Pigmentary Traits Pleiotropy Using PRS in the GCAT Cohort.

Farre X, Blay N, Cortes B, Carreras A, Iraola-Guzman S, de Cid R Genes (Basel). 2023; 14(1).

PMID: 36672889 PMC: 9859115. DOI: 10.3390/genes14010149.

Systematic review of Mendelian randomization studies on risk of cancer.

Markozannes G, Kanellopoulou A, Dimopoulou O, Kosmidis D, Zhang X, Wang L BMC Med. 2022; 20(1):41.

PMID: 35105367 PMC: 8809022. DOI: 10.1186/s12916-022-02246-y.

The silent variants of pituitary tumors: demographic, radiological and molecular characteristics.

Torregrosa-Quesada M, Garcia-Martinez A, Sanchez-Barbie A, Silva-Ortega S, Camara R, Fajardo C J Endocrinol Invest. 2021; 44(8):1637-1648.

PMID: 33476035 DOI: 10.1007/s40618-020-01468-2.

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