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Light-Driven Enzymatic Decarboxylation of Fatty Acids

Overview
Journal Angew Chem Int Ed Engl
Specialty Chemistry
Date 2018 Aug 15
PMID 30106504
Citations 26
Authors
Mieke M E Huijbers
Wuyuan Zhang
Fabio Tonin
Frank Hollmann
Affiliations
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Abstract

The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate the irreversible preparation of alkanes from fatty acids and triglycerides. Several fatty acids and their triglycerides are converted by CvFAP in near-quantitative yield and exclusive selectivity upon illumination with blue light. Very promising turnover numbers of up to 8000 were achieved in this proof-of-concept study.

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