MicroRNAs in Cardiac Autophagy: Small Molecules and Big Role

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2018 Aug 15

PMID 30103495

Citations 31

Authors

Teng Sun

Meng-Yang Li

Pei-Feng Li

Ji-Min Cao

Affiliations

Soon will be listed here.

Abstract

Autophagy, which is an evolutionarily conserved process according to the lysosomal degradation of cellular components, plays a critical role in maintaining cell homeostasis. Autophagy and mitochondria autophagy (mitophagy) contribute to the preservation of cardiac homeostasis in physiological settings. However, impaired or excessive autophagy is related to a variety of diseases. Recently, a close link between autophagy and cardiac disorders, including myocardial infarction, cardiac hypertrophy, cardiomyopathy, cardiac fibrosis, and heart failure, has been demonstrated. MicroRNAs (miRNAs) are a class of small non-coding RNAs with a length of approximately 21⁻22 nucleotides (nt), which are distributed widely in viruses, plants, protists, and animals. They function in mediating the post-transcriptional gene silencing. A growing number of studies have demonstrated that miRNAs regulate cardiac autophagy by suppressing the expression of autophagy-related genes in a targeted manner, which are involved in the pathogenesis of heart diseases. This review summarizes the role of microRNAs in cardiac autophagy and related cardiac disorders. Furthermore, we mainly focused on the autophagy regulation pathways, which consisted of miRNAs and their targeted genes.

Citing Articles

Identification of homer protein homolog 3 as a prognostic marker of colon adenocarcinoma.

Luo M, Zhao C, Zhao Y, Wang Y, Li P Heliyon. 2024; 10(13):e33344.

PMID: 39035486 PMC: 11259827. DOI: 10.1016/j.heliyon.2024.e33344.

Functional polymorphism in miR-208 is associated with increased risk for ischemic stroke.

Liu C, Luo Y, Chen J, Weng Y, Lan Y, Liu H BMC Med Genomics. 2023; 16(1):176.

PMID: 37525251 PMC: 10391967. DOI: 10.1186/s12920-023-01610-y.

Identification and Characterization of Development-Related microRNAs in the Red Flour Beetle, .

Li C, Wu W, Tang J, Feng F, Chen P, Li B Int J Mol Sci. 2023; 24(7).

PMID: 37047657 PMC: 10094939. DOI: 10.3390/ijms24076685.

IDH2 Deficiency Promotes Endothelial Senescence by Eliciting miR-34b/c-Mediated Suppression of Mitophagy and Increased ROS Production.

Lee I, Piao S, Kim S, Nagar H, Choi S, Kim M Antioxidants (Basel). 2023; 12(3).

PMID: 36978833 PMC: 10045915. DOI: 10.3390/antiox12030585.

MiR-130a-3p regulates FUNDC1-mediated mitophagy by targeting GJA1 in myocardial ischemia/reperfusion injury.

Yan Y, Tian L, Jia Q, Han Y, Tian Y, Chen H Cell Death Discov. 2023; 9(1):77.

PMID: 36841811 PMC: 9968299. DOI: 10.1038/s41420-023-01372-7.

References

Cummins N, Gotz J . Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?. Cell Mol Life Sci. 2017; 75(7):1151-1162. PMC: 11105538. DOI: 10.1007/s00018-017-2692-9. View

Hou W, Song L, Zhao Y, Liu Q, Zhang S . Inhibition of Beclin-1-Mediated Autophagy by MicroRNA-17-5p Enhanced the Radiosensitivity of Glioma Cells. Oncol Res. 2017; 25(1):43-53. PMC: 7840760. DOI: 10.3727/096504016X14719078133285. View

Dorn 2nd G . Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors. J Cardiovasc Transl Res. 2010; 3(4):374-83. PMC: 2900478. DOI: 10.1007/s12265-010-9174-x. View

Wang K, Liu C, Zhou L, Wang J, Wang M, Zhao B . APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p. Nat Commun. 2015; 6:6779. DOI: 10.1038/ncomms7779. View

Liu H, Dai C, Fan Y, Guo B, Ren K, Sun T . From autophagy to mitophagy: the roles of P62 in neurodegenerative diseases. J Bioenerg Biomembr. 2017; 49(5):413-422. DOI: 10.1007/s10863-017-9727-7. View

Eulalio A, Huntzinger E, Izaurralde E . Getting to the root of miRNA-mediated gene silencing. Cell. 2008; 132(1):9-14. DOI: 10.1016/j.cell.2007.12.024. View

Li W, Zhang X, Zhuang H, Chen H, Chen Y, Tian W . MicroRNA-137 is a novel hypoxia-responsive microRNA that inhibits mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX. J Biol Chem. 2014; 289(15):10691-10701. PMC: 4036186. DOI: 10.1074/jbc.M113.537050. View

Chen H, Zhang Z, Lu Y, Song K, Liu X, Xia F . Downregulation of ULK1 by microRNA-372 inhibits the survival of human pancreatic adenocarcinoma cells. Cancer Sci. 2017; 108(9):1811-1819. PMC: 5581518. DOI: 10.1111/cas.13315. View

Zou M, Wang F, Gao R, Wu J, Ou Y, Chen X . Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-β R II during TGF-β1-induced fibrogenesis in human cardiac fibroblasts. Sci Rep. 2016; 6:24747. PMC: 4838850. DOI: 10.1038/srep24747. View

10.

Sun A, Meng F, Wang M . CISD2 promotes the proliferation of glioma cells via suppressing beclin‑1‑mediated autophagy and is targeted by microRNA‑449a. Mol Med Rep. 2017; 16(6):7939-7948. PMC: 5779876. DOI: 10.3892/mmr.2017.7642. View

11.

Wang C, Zhang Z, Yang W, Ouyang Z, Xue J, Li X . MiR-210 facilitates ECM degradation by suppressing autophagy via silencing of ATG7 in human degenerated NP cells. Biomed Pharmacother. 2017; 93:470-479. DOI: 10.1016/j.biopha.2017.06.048. View

12.

He C, Klionsky D . Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 2009; 43:67-93. PMC: 2831538. DOI: 10.1146/annurev-genet-102808-114910. View

13.

Kim J, Fiesel F, Belmonte K, Hudec R, Wang W, Kim C . miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1). Mol Neurodegener. 2016; 11(1):55. PMC: 4960690. DOI: 10.1186/s13024-016-0121-4. View

14.

Wan G, Xie W, Liu Z, Xu W, Lao Y, Huang N . Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2013; 10(1):70-9. PMC: 4389881. DOI: 10.4161/auto.26534. View

15.

Su M, Chen Z, Wang C, Song L, Zou Y, Zhang L . Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice. Cell Physiol Biochem. 2016; 39(4):1503-11. DOI: 10.1159/000447853. View

16.

Zhao K, Zhang Y, Kang L, Song Y, Wang K, Li S . Methylation of microRNA-129-5P modulates nucleus pulposus cell autophagy by targeting Beclin-1 in intervertebral disc degeneration. Oncotarget. 2017; 8(49):86264-86276. PMC: 5689683. DOI: 10.18632/oncotarget.21137. View

17.

Huang Y, Guerrero-Preston R, Ratovitski E . Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation. Cell Cycle. 2012; 11(6):1247-59. PMC: 3335921. DOI: 10.4161/cc.11.6.19670. View

18.

Rothschild S, Gautschi O, Batliner J, Gugger M, Fey M, Tschan M . MicroRNA-106a targets autophagy and enhances sensitivity of lung cancer cells to Src inhibitors. Lung Cancer. 2016; 107:73-83. DOI: 10.1016/j.lungcan.2016.06.004. View

19.

Hutvagner G, McLachlan J, Pasquinelli A, Balint E, Tuschl T, Zamore P . A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 2001; 293(5531):834-8. DOI: 10.1126/science.1062961. View

20.

Yan C, Li T . Dual Role of Mitophagy in Cancer Drug Resistance. Anticancer Res. 2018; 38(2):617-621. DOI: 10.21873/anticanres.12266. View