Radicals in Natural Product Synthesis

Overview

Journal Chem Soc Rev

Specialty Chemistry

Date 2018 Aug 14

PMID 30101272

Citations 52

Authors

Kevin J Romero

Matthew S Galliher

Derek A Pratt

Corey R J Stephenson

Affiliations

Soon will be listed here.

Abstract

Free radical intermediates have intrigued chemists since their discovery, and an ever-increasing appreciation for their unique reactivity has resulted in the widespread utilization of these species throughout the field of chemical synthesis. This is most evident from the recent surge in the application of intermolecular radical reactions that feature in complex molecule syntheses. This tutorial review will discuss the diverse methods utilized for radical generation and reactivity to form critical bonds in natural product total synthesis. In particular, stabilized (e.g. benzyl) and persistent (e.g. TEMPO) radicals will be the primary focus.

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