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Antibacterial Activity of Netilmicin, a New Aminoglycoside Antibiotic, Compared with That of Gentamicin

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1977 Mar 1
PMID 301004
Citations 7
Authors
I Phillips
A Smith
K Shannon
Affiliations
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Abstract

The antibacterial activity of netilmicin (Sch 20569), a new semisynthetic aminoglycoside, was compared with that of gentamicin against a variety of gram-negative bacteria, staphylococci, and streptococci. Both antibiotics had similar activity against most organisms, but netilmicin had appreciably greater activity against gram-negative organisms that were resistant to gentamicin because these species synthesized aminoglycoside 3-N-acetyltransferase I or aminoglycoside 2''-O-nucleotidyltransferase. Netilmicin was also more active than gentamicin against gentamicin-resistant strains of Staphylococcus aureus that produced two enzymes-aminoglycoside-2''-O-phosphotransferase and aminoglycoside-6'-N-acetyltransferase.

Citing Articles

Tentative interpretive criteria for the diffusion susceptibility test using 30-microgram netilmicin disks.

Jones R, Barry A, Thornsberry C Antimicrob Agents Chemother. 1980; 18(3):487-90.

PMID: 7425615 PMC: 284029. DOI: 10.1128/AAC.18.3.487.

Assay of netilmicin, using enzyme immunoassay for gentamicin.

Larson T, Gerding D, Peterson L, Eckfeldt J Antimicrob Agents Chemother. 1982; 21(3):399-401.

PMID: 7049074 PMC: 181903. DOI: 10.1128/AAC.21.3.399.

Antibiotic prophylaxis in cardiothoracic surgery in the United Kingdom: current practice.

Wilson A, Treasure T, Sturridge M, Gruneberg R Thorax. 1986; 41(5):396-400.

PMID: 3750246 PMC: 1020634. DOI: 10.1136/thx.41.5.396.

High-pressure liquid chromatographic assay of netilmicin in plasma.

Peng G, JACKSON G, Chiou W Antimicrob Agents Chemother. 1977; 12(6):707-9.

PMID: 931368 PMC: 430008. DOI: 10.1128/AAC.12.6.707.

Aminoglycoside modification by gentamicin-resistant isolates of Staphylococcus aureus.

Scott D, Wood D, Brownell G, Carter M, BEST G Antimicrob Agents Chemother. 1978; 13(4):641-4.

PMID: 666292 PMC: 352303. DOI: 10.1128/AAC.13.4.641.

References
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