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The CeNGEN Project: The Complete Gene Expression Map of an Entire Nervous System

Overview
Journal Neuron
Publisher Cell Press
Specialty Neurology
Date 2018 Aug 10
PMID 30092212
Citations 66
Authors
Marc Hammarlund
Oliver Hobert
David M Miller 3rd
Nenad Sestan
Affiliations
Soon will be listed here.
Abstract

Differential gene expression defines individual neuron types and determines how each contributes to circuit physiology and responds to injury and disease. The C. elegans Neuronal Gene Expression Map & Network (CeNGEN) will establish a comprehensive gene expression atlas of an entire nervous system at single-neuron resolution.

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References
1.
Sulston J, Horvitz H . Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol. 1977; 56(1):110-56. DOI: 10.1016/0012-1606(77)90158-0. View
2.
Oren-Suissa M, Bayer E, Hobert O . Sex-specific pruning of neuronal synapses in Caenorhabditis elegans. Nature. 2016; 533(7602):206-11. PMC: 4865429. DOI: 10.1038/nature17977. View
3.
Hobert O, Glenwinkel L, White J . Revisiting Neuronal Cell Type Classification in Caenorhabditis elegans. Curr Biol. 2016; 26(22):R1197-R1203. DOI: 10.1016/j.cub.2016.10.027. View
4.
Prevedel R, Yoon Y, Hoffmann M, Pak N, Wetzstein G, Kato S . Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy. Nat Methods. 2014; 11(7):727-730. PMC: 4100252. DOI: 10.1038/nmeth.2964. View
5.
Spencer W, McWhirter R, Miller T, Strasbourger P, Thompson O, Hillier L . Isolation of specific neurons from C. elegans larvae for gene expression profiling. PLoS One. 2014; 9(11):e112102. PMC: 4221280. DOI: 10.1371/journal.pone.0112102. View