Allergic Bronchopulmonary Mycosis - Pathophysiology, Histology, Diagnosis, and Treatment

Overview

Journal Asia Pac Allergy

Publisher Wolters Kluwer

Date 2018 Aug 7

PMID 30079302

Citations 17

Authors

Koichiro Asano

Katsuhiko Kamei

Akira Hebisawa

Affiliations

Soon will be listed here.

Abstract

Allergic bronchopulmonary mycosis (ABPM) develops mainly in patients with asthma or cystic fibrosis via types I and III hypersensitivity reactions to filamentous fungi. spp., especially , is the major causative fungus because of its small conidia, thermophilic hyphae, and ability to secrete serine proteases. The cardinal histological feature of ABPM is allergic (eosinophilic) mucin-harboring hyphae in the bronchi, for which the formation of extracellular DNA trap cell death (ETosis) of eosinophils induced by viable fungi is essential. Clinically, ABPM is characterized by peripheral blood eosinophilia, increased IgE levels in the serum, IgE and IgG antibodies specific for fungi, and characteristic radiographic findings; however, there are substantial differences in the clinical features of this disease between East and South Asian populations. Systemic corticosteroids and/or antifungal drugs effectively control acute diseases, but recurrences are quite common, and development of novel treatments are warranted to avoid adverse effects and emergence of drug-resistance due to prolonged treatment with corticosteroids and/or antifungal drugs.

Citing Articles

Refractory phenotype of -sensitized asthma with bronchiectasis and allergic bronchopulmonary aspergillosis.

Nomura N, Matsumoto H, Asano K, Hayashi Y, Yokoyama A, Nishimura Y J Allergy Clin Immunol Glob. 2024; 4(1):100364.

PMID: 39659740 PMC: 11629325. DOI: 10.1016/j.jacig.2024.100364.

Allergic Bronchopulmonary Candidiasis: An Uncommon Case of Hypereosinophilia.

Mora Pinilla J, Garcia Garcia A, Matesanz Lopez C, Raboso Moreno B Open Respir Arch. 2024; 6(4):100370.

PMID: 39650746 PMC: 11625117. DOI: 10.1016/j.opresp.2024.100370.

A Case of Allergic Bronchopulmonary Mycosis Caused by Cordyceps farinosa, a Species of Caterpillar Fungi.

Sakano Y, Okumura T, Kofuku T, Kidaka S, Nakata Y, Katsura S Cureus. 2024; 16(9):e68366.

PMID: 39355473 PMC: 11443473. DOI: 10.7759/cureus.68366.

Allergic Bronchopulmonary Aspergillosis/Mycosis: An Allergic Disease or an Eosinophilic Disease?.

Asano K, Oguma T Intern Med. 2024; 64(4):493-501.

PMID: 39231658 PMC: 11904459. DOI: 10.2169/internalmedicine.4386-24.

Efficacy of dupilumab as an alternative to corticosteroids in the treatment of exacerbations of allergic bronchopulmonary aspergillosis.

Hamakawa M, Ishida T Respirol Case Rep. 2024; 12(4):e01354.

PMID: 38617121 PMC: 11009483. DOI: 10.1002/rcr2.1354.

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