The Emerging Role of MiR-19 in Glioma

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2018 Aug 4

PMID 30073755

Citations 20

Authors

Weihan Wang

Anling Zhang

Yubing Hao

Guangxiu Wang

Zhifan Jia

Affiliations

Soon will be listed here.

Abstract

Glioma has been regarded as the most common, highly proliferative and invasive brain tumour. Advances in research of miRNAs in glioma are toward further understanding of the pathogenesis of glioma. MiR-19, a member of miR-17~92 cluster, was reported to play an oncogenic role in tumourigenesis. Here we review the identified data about the effect of miR-19 on proliferation, apoptosis, migration and invasion of glioma cells, the target genes regulated by miR-19, and correlation of miR-19 with the sensitivity of glioma cells to chemotherapy and radiotherapy. It is concluded that miR-19 plays an important role in the pathogenesis of glioma and can be a potential target for gene therapy of glioma.

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