Study of the Room-Temperature Synthesis of Oxime Ethers by Using a Super Base

Overview

Journal ChemistryOpen

Specialty Chemistry

Date 2018 Aug 2

PMID 30065906

Citations 2

Authors

Tomasz Kosmalski

Renata Studzinska

Natalia Daniszewska

Malgorzata Ullrich

Adam Sikora

Michal Marszall

Bozena Modzelewska-Banachiewicz

Affiliations

Soon will be listed here.

Abstract

In this study, we present a convenient method for the synthesis of oxime ethers by reacting oximes with various chlorides (alkyl, functionalized alkyl, and benzyl) and with the subsequent use of a super base-pulverized potassium hydroxide in DMSO. The reactions take place at room temperature and the products are obtained in high yields. The final products were received within 2 min to 3 h. In addition, the compounds do not require chromatographic separation. The structure elucidation of the titled compounds was performed by using H NMR and C NMR spectroscopy as well as mass spectrometry. The presented method of synthesis for oxime ethers is environmentally friendly, because neither water cooling or heating of the reaction mixture/solvents (necessary for chromatographic purification) is required. The synthesis can be carried out very easily on a large scale.

Citing Articles

The Oxime Ethers with Heterocyclic, Alicyclic and Aromatic Moiety as Potential Anti-Cancer Agents.

Kosmalski T, Hetmann A, Studzinska R, Baumgart S, Kupczyk D, Roszek K Molecules. 2022; 27(4).

PMID: 35209155 PMC: 8878717. DOI: 10.3390/molecules27041374.

Study of the Room-Temperature Synthesis of Oxime Ethers by using a Super Base.

Kosmalski T, Studzinska R, Daniszewska N, Ullrich M, Sikora A, Marszall M ChemistryOpen. 2018; 7(7):551-557.

PMID: 30065906 PMC: 6058178. DOI: 10.1002/open.201800098.

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