Tectorigenin Inhibits RANKL-induced Osteoclastogenesis Via Suppression of NF-κB Signalling and Decreases Bone Loss in Ovariectomized C57BL/6

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2018 Aug 1

PMID 30063119

Citations 5

Authors

Chiyuan Ma

Kai Xu

Jiahong Meng

Jisheng Ran

Safwat Adel Abdo Moqbel

An Liu

Shigui Yan

Lidong Wu

Affiliations

Soon will be listed here.

Abstract

Metabolism of bone is regulated by the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption. Activation of osteoclasts could lead to osteoporosis. Thus, inhibiting the activity of osteoclasts becomes an available strategy for the treatment of osteoporosis. Tectorigenin is an extract of Belamcanda chinensis In the present study, the anti-osteoclastogenesis effects of tectorigenin were investigated in vitro and in vivo. The results showed preventive and therapeutic effects of tectorigenin at concentrations of 0, 10, 40, and 80 μmol/L in the maturation and activation of osteoclasts. A signalling study also indicated that tectorigenin treatment reduces activation of NF-κB signalling in osteoclastogenesis. Animal experiment demonstrated that tectorigenin treatment (1-10 mg/kg, abdominal injection every 3 days) significantly inhibits bone loss in ovariectomized C57BL/6. Our data suggest that tectorigenin is a potential pharmacological choice for osteoporosis.

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Tectorigenin inhibits RANKL-induced osteoclastogenesis via suppression of NF-κB signalling and decreases bone loss in ovariectomized C57BL/6.

Ma C, Xu K, Meng J, Ran J, Adel Abdo Moqbel S, Liu A J Cell Mol Med. 2018; 22(10):5121-5131.

PMID: 30063119 PMC: 6156464. DOI: 10.1111/jcmm.13801.

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