» Articles » PMID: 3005002

Serotonin 5-HT1 Receptors Mediate Inhibition of Cyclic AMP Production in Neurons

Overview
Journal Eur J Pharmacol
Specialty Pharmacology
Date 1986 Jan 21
PMID 3005002
Citations 15
Authors
Affiliations
Soon will be listed here.
Abstract

In purified striatal and cortical neurons in primary culture, serotonin (5-HT) stimulated basal cyclic AMP production (EC50, 0.5 microM) 2.5- and 1.5-fold, respectively. The 5-HT1 selective agonists, RU 24969 and 8-hydroxy-2-(di-n-propylamino)tetralin (PAT), did not stimulate cyclic AMP production. However, 5-HT, RU 24969 and PAT inhibited VIP-stimulated cyclic AMP formation in a dose-dependent manner. The actions of selective agonists and antagonists at 5-HT receptors mediating attenuation of cyclic AMP production suggest that they may be of the 5-HT1 subtype.

Citing Articles

Chronic, but not sub-chronic, stress increases binge-like alcohol consumption in male and female c57BL6 mice.

McCarthy W, Huq S, Allen K, Scally L, Petri A, Wujek M Front Behav Neurosci. 2022; 16:958342.

PMID: 36204485 PMC: 9530781. DOI: 10.3389/fnbeh.2022.958342.


Increasing serotonin bioavailability alters gene expression in peripheral leukocytes and lymphoid tissues of dairy calves.

Marrero M, Field S, Skibiel A, Dado-Senn B, Driver J, Laporta J Sci Rep. 2020; 10(1):9712.

PMID: 32546841 PMC: 7297988. DOI: 10.1038/s41598-020-66326-w.


Allosteric Inhibition of Serotonin 5-HT Receptors by Zinc Ions.

Satala G, Duszynska B, Lenda T, Nowak G, Bojarski A Mol Neurobiol. 2017; 55(4):2897-2910.

PMID: 28455702 PMC: 5842505. DOI: 10.1007/s12035-017-0536-0.


The PKC inhibitor, bisindolymaleimide, blocks DOI's attenuation of the effects of 8-OH-DPAT on female rat lordosis behavior.

Selvamani A, Lincoln C, Uphouse L Behav Brain Res. 2007; 179(1):99-106.

PMID: 17336403 PMC: 1950743. DOI: 10.1016/j.bbr.2007.01.015.


The serotonin1A receptor: a representative member of the serotonin receptor family.

Pucadyil T, Kalipatnapu S, Chattopadhyay A Cell Mol Neurobiol. 2005; 25(3-4):553-80.

PMID: 16075379 PMC: 11529526. DOI: 10.1007/s10571-005-3969-3.