Proteolytic Processing of Platelet Receptors

Overview

Journal Res Pract Thromb Haemost

Publisher Elsevier

Date 2018 Jul 27

PMID 30046726

Citations 18

Authors

Elizabeth E Gardiner

Affiliations

Soon will be listed here.

Abstract

Platelets have a major role in hemostasis and an emerging role in biological processes including inflammation and immunity. Many of these processes require platelet adhesion and localization at sites of tissue damage or infection and regulated platelet activation, mediated by platelet adheso-signalling receptors, glycoprotein (GP) Ib-IX-V and GPVI. Work from a number of laboratories has demonstrated that levels of these receptors are closely regulated by metalloproteinases of the A Disintegrin And Metalloproteinase (ADAM) family, primarily ADAM17 and ADAM10. It is becoming increasingly evident that platelets have important roles in innate immunity, inflammation, and in combating infection that extends beyond processes of hemostasis. This overview will examine the molecular events that regulate levels of platelet receptors and then assess ramifications for these events in settings where hemostasis, inflammation, and infection processes are triggered.

Citing Articles

A Novel P-III Metalloproteinase from Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via α5β1 Integrin Receptors to Arginine-Glycine-Aspartic Acid (RGD)-Containing Molecules.

Schluga P, Larangote D, de Melo A, Lobermayer G, Torrejon D, Souza de Oliveira L Toxins (Basel). 2024; 16(11).

PMID: 39591241 PMC: 11597958. DOI: 10.3390/toxins16110486.

Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target.

Benson T, Pike M, Spuzzillo A, Hicks S, Ali S, Pham M Blood. 2024; 144(16):1663-1678.

PMID: 38900973 PMC: 11522893. DOI: 10.1182/blood.2023021655.

GP5 regulates epithelial-mesenchymal transition in breast cancer via the PI3K/AKT signaling pathway.

Xiang K, Yanshan H, Chunmei Z, Minmin G, Yan W, Xiaojia Y Exp Biol Med (Maywood). 2022; 247(17):1501-1517.

PMID: 35880886 PMC: 9554163. DOI: 10.1177/15353702221110642.

Functional changes in hemostasis during asexual and sexual parasitemia in a controlled human malaria infection.

Huang S, van der Heijden W, Reuling I, Wan J, Yan Q, de Laat-Kremers R PLoS One. 2022; 17(7):e0271527.

PMID: 35839244 PMC: 9286275. DOI: 10.1371/journal.pone.0271527.

Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation.

Neagoe R, Gardiner E, Stegner D, Nieswandt B, Watson S, Poulter N Int J Mol Sci. 2022; 23(7).

PMID: 35409124 PMC: 8998833. DOI: 10.3390/ijms23073746.

References

Boylan B, Chen H, Rathore V, Paddock C, Salacz M, Friedman K . Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. Blood. 2004; 104(5):1350-5. DOI: 10.1182/blood-2004-03-0896. View

Bynagari-Settipalli Y, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J . Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol. 2014; 34(12):2563-9. PMC: 4239193. DOI: 10.1161/ATVBAHA.114.304244. View

Andrews R, Gardiner E . Basic mechanisms of platelet receptor shedding. Platelets. 2016; 28(4):319-324. DOI: 10.1080/09537104.2016.1235690. View

Nieswandt B, Schulte V, Bergmeier W, Mokhtari-Nejad R, Rackebrandt K, Cazenave J . Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J Exp Med. 2001; 193(4):459-69. PMC: 2195902. DOI: 10.1084/jem.193.4.459. View

Gardiner E, Karunakaran D, Shen Y, Arthur J, Andrews R, Berndt M . Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. J Thromb Haemost. 2007; 5(7):1530-7. DOI: 10.1111/j.1538-7836.2007.02590.x. View

Shen Y, Romo G, Dong J, Schade A, McIntire L, Kenny D . Requirement of leucine-rich repeats of glycoprotein (GP) Ibalpha for shear-dependent and static binding of von Willebrand factor to the platelet membrane GP Ib-IX-V complex. Blood. 2000; 95(3):903-10. View

Ruan C, Du X, Xi X, Castaldi P, Berndt M . A murine antiglycoprotein Ib complex monoclonal antibody, SZ 2, inhibits platelet aggregation induced by both ristocetin and collagen. Blood. 1987; 69(2):570-7. View

Coenen D, Mastenbroek T, Cosemans J . Platelet interaction with activated endothelium: mechanistic insights from microfluidics. Blood. 2017; 130(26):2819-2828. DOI: 10.1182/blood-2017-04-780825. View

Coller B, Kalomiris E, Steinberg M, Scudder L . Evidence that glycocalicin circulates in normal plasma. J Clin Invest. 1984; 73(3):794-9. PMC: 425082. DOI: 10.1172/JCI111273. View

10.

Kehrel B, Wierwille S, Clemetson K, Anders O, Steiner M, Knight C . Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not. Blood. 1998; 91(2):491-9. View

11.

Gardiner E, Arthur J, Kahn M, Berndt M, Andrews R . Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. Blood. 2004; 104(12):3611-7. DOI: 10.1182/blood-2004-04-1549. View

12.

Welsh J, Poventud-Fuentes I, Sampietro S, Diamond S, Stalker T, Brass L . Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature. J Thromb Haemost. 2016; 15(3):526-537. PMC: 5334252. DOI: 10.1111/jth.13600. View

13.

Jung S, Moroi M, Soejima K, Nakagaki T, Miura Y, Berndt M . Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood. J Biol Chem. 2012; 287(35):30000-13. PMC: 3436176. DOI: 10.1074/jbc.M112.359125. View

14.

Furman M, Nurden P, Berndt M, Nurden A, Benoit S, Barnard M . The cleaved peptide of PAR1 results in a redistribution of the platelet surface GPIb-IX-V complex to the surface-connected canalicular system. Thromb Haemost. 2000; 84(5):897-903. View

15.

Grozovsky R, Giannini S, Falet H, Hoffmeister K . Regulating billions of blood platelets: glycans and beyond. Blood. 2015; 126(16):1877-84. PMC: 4608239. DOI: 10.1182/blood-2015-01-569129. View

16.

Trivedi V, Boire A, Tchernychev B, Kaneider N, Leger A, OCallaghan K . Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site. Cell. 2009; 137(2):332-43. PMC: 2807741. DOI: 10.1016/j.cell.2009.02.018. View

17.

Adrain C, Zettl M, Christova Y, Taylor N, Freeman M . Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science. 2012; 335(6065):225-8. PMC: 3272371. DOI: 10.1126/science.1214400. View

18.

Nurden A, Nurden P . Advances in our understanding of the molecular basis of disorders of platelet function. J Thromb Haemost. 2011; 9 Suppl 1:76-91. DOI: 10.1111/j.1538-7836.2011.04274.x. View

19.

McEwan P, Andrews R, Emsley J . Glycoprotein Ibalpha inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism. Blood. 2009; 114(23):4883-5. DOI: 10.1182/blood-2009-05-224170. View

20.

Lisi S, DAmore M, Sisto M . ADAM17 at the interface between inflammation and autoimmunity. Immunol Lett. 2014; 162(1 Pt A):159-69. DOI: 10.1016/j.imlet.2014.08.008. View