A Copper-mediated Reverse Aromatic Finkelstein Reaction in Ionic Liquid

Overview

Journal J Adv Res

Specialties General Medicine
Science

Date 2018 Jul 27

PMID 30046471

Authors

Anh T H Nguyen

Dat P Nguyen

Ngan T K Phan

Dung T T Lam

Nam T S Phan

Thanh Truong

Affiliations

Soon will be listed here.

Abstract

We have developed a general method for reverse aromatic Finkelstein reactions. Good reaction yields were obtained when aryl iodides or aryl bromides were treated with copper halide salts as promoters in a 1-butyl-3-methylimidazolium bromide ([BMIM]Br) ionic liquid (IL) solvent at 140 °C for 8 h. Preliminary investigation supported that the copper salts were also the halide sources in halogen exchange reactions. The optimized conditions are applicable to a variety of substrates and have excellent functional group tolerance. Additionally, the [BMIM]Br solvent showed good stability for at least 10 consecutive runs. Results indicated that the [BMIM]Br solvent was recyclable for reverse aromatic Finkelstein reactions.

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