Positron Emission Tomography-computed Tomography for Inguinal Nodes in Vulvar Cancer

Overview

Journal World J Nucl Med

Publisher Thieme

Specialty Nuclear Medicine

Date 2018 Jul 24

PMID 30034276

Citations 7

Authors

Jorge Daniel Oldan

Stephanie A Sullivan

Affiliations

Soon will be listed here.

Abstract

We aimed to determine the sensitivity and specificity of fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) for the spread of disease to inguinal lymph nodes in vulvar cancer. A retrospective review of vulvar cancer patients who underwent both inguinal nodal sampling and dissection as well as FDG PET-CT was performed, with 21 patients meeting criteria. The sensitivity and specificity of the FDG PET-CT imaging was performed using a combination of maximum standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Using an SUVcutoff of 4.5 or of two times the average liver uptake, we had a 100% sensitivity and 89% specificity for positive inguinal nodes. MTV and TLG did not add to sensitivity or specificity. We conclude that FDG PET-CT has good sensitivity for inguinal nodal spread in vulvar cancer, and either a quantitative or semiquantitative approach is effective.

Citing Articles

Imaging in Vulval Cancer.

Ha M, Eva L Cancers (Basel). 2024; 16(12).

PMID: 38927973 PMC: 11201686. DOI: 10.3390/cancers16122269.

Current Preoperative Management of Vulvar Squamous Cell Carcinoma: An Overview.

Della Corte L, Cafasso V, Guarino M, Gullo G, Cucinella G, Lopez A Cancers (Basel). 2024; 16(10).

PMID: 38791925 PMC: 11119127. DOI: 10.3390/cancers16101846.

18F-FDG PET/MRI and 18F-FDG PET/CT for the Management of Gynecological Malignancies: A Comprehensive Review of the Literature.

Allahqoli L, Hakimi S, Lagana A, Momenimovahed Z, Mazidimoradi A, Rahmani A J Imaging. 2023; 9(10).

PMID: 37888330 PMC: 10607780. DOI: 10.3390/jimaging9100223.

PET-CT in Clinical Adult Oncology-IV. Gynecologic and Genitourinary Malignancies.

Salem A, Fine G, Covington M, Koppula B, Wiggins R, Hoffman J Cancers (Basel). 2022; 14(12).

PMID: 35740665 PMC: 9220973. DOI: 10.3390/cancers14123000.

Vulvar cancer staging: guidelines of the European Society of Urogenital Radiology (ESUR).

Nikolic O, Alves E Sousa F, Cunha T, Nikolic M, Otero-Garcia M, Gui B Insights Imaging. 2021; 12(1):131.

PMID: 34550489 PMC: 8458511. DOI: 10.1186/s13244-021-01075-6.

References

Peiro V, Chiva L, Gonzalez A, Bratos R, Alonso S, Marquez R . [Utility of the PET/CT in vulvar cancer management]. Rev Esp Med Nucl Imagen Mol. 2013; 33(2):87-92. DOI: 10.1016/j.remn.2013.07.009. View

Cohn D, Dehdashti F, Gibb R, Mutch D, Rader J, Siegel B . Prospective evaluation of positron emission tomography for the detection of groin node metastases from vulvar cancer. Gynecol Oncol. 2002; 85(1):179-84. DOI: 10.1006/gyno.2002.6605. View

Kamran M, OToole F, Meghen K, Wahab A, Saadeh F, Gleeson N . Whole-body [18F]fluoro-2-deoxyglucose positron emission tomography scan as combined PET-CT staging prior to planned radical vulvectomy and inguinofemoral lymphadenectomy for squamous vulvar cancer: a correlation with groin node metastasis. Eur J Gynaecol Oncol. 2014; 35(3):230-5. View

Adams M, Turkington T, Wilson J, Wong T . A systematic review of the factors affecting accuracy of SUV measurements. AJR Am J Roentgenol. 2010; 195(2):310-20. DOI: 10.2214/AJR.10.4923. View

Gaarenstroom K, Kenter G, Trimbos J, Agous I, Amant F, Peters A . Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions. Int J Gynecol Cancer. 2003; 13(4):522-7. DOI: 10.1046/j.1525-1438.2003.13304.x. View