Ovarian Tissue Cryopreservation and Transplantation in Patients with Cancer

Overview

Journal Obstet Gynecol Sci

Specialty Gynecology & Obstetrics

Date 2018 Jul 19

PMID 30018897

Citations 40

Authors

Sooyoung Kim

Younji Lee

Sanghoon Lee

Tak Kim

Affiliations

Soon will be listed here.

Abstract

Chemotherapy and radiotherapy improved survival rates of patients with cancer. However, they can cause ovarian failure and infertility in women of reproductive age. Infertility following cancer treatment is considered a major quality of life issue. Ovarian tissue cryopreservation and transplantation is an important option for fertility preservation in adult patients with cancer who need immediate chemotherapy or do not want to undergo ovarian stimulation. Ovarian tissue freezing is the only option for preserving the fertility of prepubertal patients with cancer. In a recent review, it was reported that frozen-thawed ovarian transplantation has lead to about 90 live births and the conception rate was about 30%. Endocrine function recovery was observed in 92.9% between 3.5 and 6.5 months after transplantation. Based on our review, ovarian tissue cryopreservation and transplantation may be carefully considered before cancer treatment in order to preserve fertility and endocrine function in young cancer survivors.

Citing Articles

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation.

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Ovarian tissue transplantation: 10 years of experience at the Bologna University.

Fabbri R, Vicenti R, Magnani V, Paradisi R, de Meis L, Raimondo D Front Endocrinol (Lausanne). 2024; 15:1332673.

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Comparative effects of a calcium chelator (BAPTA-AM) and melatonin on cryopreservation-induced oxidative stress and damage in ovarian tissue.

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Assessing the impact of transplant site on ovarian tissue transplantation: a single-arm meta-analysis.

Xie B, Li J, Huang Y, Hang F, Hu Q, Yu J Reprod Biol Endocrinol. 2023; 21(1):120.

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Optimizing the Ovarian Tissue Cryopreservation in the 'Oncofertility' Institutional Program at an Italian National Cancer Institute.

Silvestris E, Minoia C, De Palma G, Popescu O, Altavilla A, Guarini A Healthcare (Basel). 2023; 11(20).

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