Alpha 2.0
Login Register
» Articles » PMID: 3000290

Effect of Pyrimidinone Treatment on Lethal and Immunosuppressive Murine Cytomegalovirus Infection

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1985 Oct 1
PMID 3000290
Citations 4
Authors
R J Brideau
J A Wolcott
Affiliations
Soon will be listed here.
Abstract

The 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (CMV) challenge in weanling or neonatal mice when administered before virus challenge. This protection was dependent upon the dosage of pyrimidinone administered. Weanling mice infected with a sublethal challenge of CMV exhibited moderate to severe immunosuppression as measured by reduced splenic cell blastogenic responses in vitro to the mitogen concanavalin A. Treatment of mice with pyrimidinones during the course of CMV immunosuppression resulted in substantial augmentation of splenic cell blastogenic responses. The degree of augmentation appeared to be dependent on the severity of CMV-induced immunosuppression.

Citing Articles

In vivo generation of lymphokine activated killer cell activity by ABPP and interleukin-2 and their antitumor effects against immunogenic and nonimmunogenic tumors in murine tumor models.

Eggermont A, Sugarbaker P, Marquet R, Jeekel J Cancer Immunol Immunother. 1988; 26(1):23-30.

PMID: 3257900 PMC: 11038198. DOI: 10.1007/BF00199843.

Pyrimidinone (bropirimine) mediated alteration of T lymphocyte subsets during murine cytomegalovirus infection.

Brideau R, Nicholas J Clin Exp Immunol. 1987; 68(3):613-20.

PMID: 2820635 PMC: 1542767.

Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent.

Smee D, Alaghamandan H, Cottam H, Sharma B, JOLLEY W, ROBINS R Antimicrob Agents Chemother. 1989; 33(9):1487-92.

PMID: 2817849 PMC: 172688. DOI: 10.1128/AAC.33.9.1487.

Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, interferon, and bropirimine.

Smee D, Morris J, Leonhardt J, Mead J, Holy A, Sidwell R Antimicrob Agents Chemother. 1992; 36(9):1837-42.

PMID: 1329629 PMC: 192196. DOI: 10.1128/AAC.36.9.1837.

References
1.
Kelsey D, Kern E, Overall Jr J, Glasgow L . Effect of cytosine arabinoside and 5-iodo-2'-deoxyuridine on a cytomegalovirus infection in newborn mice. Antimicrob Agents Chemother. 1976; 9(3):458-64. PMC: 429552. DOI: 10.1128/AAC.9.3.458. View
2.
Stringfellow D . Comparation interferon- inducing and antiviral properties of 2-amino-5-bromo-6-methyl-4-pyrimidinol (U-25,166), tilorone hydrochloride, and polyinosinic-polycytidylic acid. Antimicrob Agents Chemother. 1977; 11(6):984-92. PMC: 352115. DOI: 10.1128/AAC.11.6.984. View
3.
Kelsey D, Overall Jr J, Glasgow L . Correlation of the suppression of mitogen responsiveness and the mixed lymphocyte reaction with the proliferative response to viral antigen of splenic lymphocytes from cytomegalovirus-infected mice. J Immunol. 1978; 121(2):464-70. View
4.
Landis J, Cooper M, Kennedy T, Koch G . A computer program for testing average partial association in three-way contingency tables (PARCAT). Comput Programs Biomed. 1979; 9(3):223-46. DOI: 10.1016/0010-468x(79)90035-7. View
5.
Wierenga W, Skulnick H, Stringfellow D, WEED S, RENIS H, Eidson E . 5-substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents. J Med Chem. 1980; 23(3):237-9. DOI: 10.1021/jm00177a004. View