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Disseminated Histoplasmosis As AIDS-presentation. Case Report and Comprehensive Review of Current Literature

Abstract

Progressive disseminated histoplasmosis (PDH) is an AIDS-defining illness with a high lethality rate if not promptly treated. The wide range of its possible clinical manifestations represents the main barrier to diagnosis in non-endemic countries. Here we present a case of PDH with haemophagocytic syndrome in a newly diagnosed HIV patient and a comprehensive review of disseminated histoplasmosis focused on epidemiology, clinical features, diagnostic tools and treatment options in HIV-infected patients.

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References
1.
Gupta N, Arora S, Rajwanshi A, Nijhawan R, Srinivasan R . Histoplasmosis: cytodiagnosis and review of literature with special emphasis on differential diagnosis on cytomorphology. Cytopathology. 2009; 21(4):240-4. DOI: 10.1111/j.1365-2303.2009.00693.x. View

2.
Diaz R, Sigler E, Rafieetary M, Calzada J . Ocular histoplasmosis syndrome. Surv Ophthalmol. 2015; 60(4):279-95. DOI: 10.1016/j.survophthal.2015.02.005. View

3.
Woods J . Revisiting old friends: Developments in understanding Histoplasma capsulatum pathogenesis. J Microbiol. 2016; 54(3):265-76. DOI: 10.1007/s12275-016-6044-5. View

4.
Guarner J, Brandt M . Histopathologic diagnosis of fungal infections in the 21st century. Clin Microbiol Rev. 2011; 24(2):247-80. PMC: 3122495. DOI: 10.1128/CMR.00053-10. View

5.
Bahr N, Antinori S, Wheat L, Sarosi G . Histoplasmosis infections worldwide: thinking outside of the Ohio River valley. Curr Trop Med Rep. 2015; 2(2):70-80. PMC: 4535725. DOI: 10.1007/s40475-015-0044-0. View