γδ T Cells: Crosstalk Between Microbiota, Chronic Inflammation, and Colorectal Cancer

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Jul 13

PMID 29997627

Citations 19

Authors

Yunben Yang

Chunjing Xu

Dang Wu

Zhen Wang

Pin Wu

Lili Li

Jian Huang

Fuming Qiu

Affiliations

Soon will be listed here.

Abstract

Increasing evidence suggests that intestinal microbiota dysbiosis and chronic inflammation contribute to colorectal cancer (CRC) development. γδ T cells represent a major innate immune cell population in the intestinal epithelium that is involved in the maintenance of gut homeostasis, inflammation regulation, and carcinogenesis. The important contributions of γδ T cells are (i) to perform a protective role in the context of barrier damage and pathogenic microorganism translocation; (ii) to exert either pro- or anti-inflammatory effects at different inflammatory stages; and (iii) to boost the crosstalk between immune cells and tumor microenvironment, inducing a cascade of suppressive immune responses. Understanding the crucial role of γδ T cells would enable us to manipulate these cells during the CRC sequence and improve the efficacy of tumor therapy.

Citing Articles

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