The Impact of the Gut Microbiota on T Cell Ontogeny in the Thymus

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2022 Apr 4

PMID 35377005

Authors

Roopa Hebbandi Nanjundappa

Channakeshava Sokke Umeshappa

Markus B Geuking

Affiliations

Soon will be listed here.

Abstract

The intestinal microbiota is critical for the development of gut-associated lymphoid tissues, including Peyer's patches and mesenteric lymph nodes, and is instrumental in educating the local as well as systemic immune system. In addition, it also impacts the development and function of peripheral organs, such as liver, lung, and the brain, in health and disease. However, whether and how the intestinal microbiota has an impact on T cell ontogeny in the hymus remains largely unclear. Recently, the impact of molecules and metabolites derived from the intestinal microbiota on T cell ontogeny in the thymus has been investigated in more detail. In this review, we will discuss the recent findings in the emerging field of the gut-thymus axis and we will highlight the current questions and challenges in the field.

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