The Utility of Ultra-widefield Fluorescein Angiography in Pediatric Retinal Diseases

Overview

Journal Int J Retina Vitreous

Publisher Biomed Central

Date 2018 Jul 12

PMID 29992045

Citations 9

Authors

Charles M Calvo

Mary Elizabeth Hartnett

Affiliations

Soon will be listed here.

Abstract

Background: Ultra-widefield angiography is the latest technology in the evolution of fundus fluorescein angiography. With the ability to capture up to 200° of the fundus in a single image, far peripheral retinal pathology can be imaged. Generally, obtaining high-quality fundus fluorescein angiography in a child without sedation in the outpatient setting is exceedingly challenging. Therefore, there are advantages to imaging platforms that can capture the peripheral retina in young children without anesthesia. Often pediatric retinal diseases have pathology localized to the far periphery, which further validates the utility of ultra-widefield angiography. Ultra-widefield angiography has been successfully used without sedation for evaluation of children with various pediatric retinal diseases such as Coats disease, familial exudative vitreoretinopathy, and retinopathy of prematurity.

Conclusion: This non-contact, non-mydriatic modality has been utilized in the evaluation of pediatric retinal diseases and demonstrated to have benefits over conventional fluorescein angiography techniques.

Citing Articles

Fluorescein Angiography Parameters in Premature Neonates.

da Cruz N, Hoyek S, Sengillo J, Rodriguez A, de Oliveira G, Negron C Ophthalmol Sci. 2024; 4(6):100561.

PMID: 39132023 PMC: 11315194. DOI: 10.1016/j.xops.2024.100561.

Vascular imaging findings in retinopathy of prematurity.

Rowe L, Belamkar A, Antman G, Hajrasouliha A, Harris A Acta Ophthalmol. 2023; 102(4):e452-e472.

PMID: 37874229 PMC: 11039572. DOI: 10.1111/aos.15800.

Anterior chamber fluorescein leakage in a child with intraocular pressure elevation and vitreous hemorrhage.

Hekmatjah N, Qureshi A, Afshar A, Oatts J Am J Ophthalmol Case Rep. 2023; 32:101935.

PMID: 37808082 PMC: 10551837. DOI: 10.1016/j.ajoc.2023.101935.

Multimodal imaging in pediatric uveitis.

Diala F, McCarthy K, Chen J, Tsui E Ther Adv Ophthalmol. 2021; 13:25158414211059244.

PMID: 34901748 PMC: 8655435. DOI: 10.1177/25158414211059244.

Aerosolised fluorescein can quantify FFP mask faceseal leakage: a cost-effective adaptation to the existing point of care fit test.

Zaman S, Seligman H, Lloyd F, Patel K, Chappell D, OHare D Clin Med (Lond). 2021; 21(3):e263-e268.

PMID: 34001582 PMC: 8140700. DOI: 10.7861/clinmed.2020-0982.

References

Lin E, Lee J, Lee C, Deng M, Loepke A . Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies. Neurotoxicol Teratol. 2016; 60:117-128. DOI: 10.1016/j.ntt.2016.10.008. View

Rabiolo A, Marchese A, Sacconi R, Cicinelli M, Grosso A, Querques L . Refining Coats' disease by ultra-widefield imaging and optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol. 2017; 255(10):1881-1890. DOI: 10.1007/s00417-017-3794-7. View

Kashani A, Brown K, Chang E, Drenser K, Capone A, Trese M . Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology. 2014; 121(11):2220-7. DOI: 10.1016/j.ophtha.2014.05.029. View

Patel C, Fung T, K Muqit M, Mordant D, Geh V . Non-contact ultra-widefield retinal imaging and fundus fluorescein angiography of an infant with incontinentia pigmenti without sedation in an ophthalmic office setting. J AAPOS. 2013; 17(3):309-11. DOI: 10.1016/j.jaapos.2012.12.152. View

ROTH D, Morales D, Feuer W, Hess D, Johnson R, Flynn J . Screening for retinopathy of prematurity employing the retcam 120: sensitivity and specificity. Arch Ophthalmol. 2001; 119(2):268-72. View

Blair M, Ulrich J, Hartnett M, Shapiro M . Peripheral retinal nonperfusion in fellow eyes in coats disease. Retina. 2013; 33(8):1694-9. DOI: 10.1097/IAE.0b013e318285cb86. View

Oliver S, Schwartz S . Peripheral vessel leakage (PVL): a new angiographic finding in diabetic retinopathy identified with ultra wide-field fluorescein angiography. Semin Ophthalmol. 2010; 25(1-2):27-33. DOI: 10.3109/08820538.2010.481239. View

. Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991; 98(5 Suppl):786-806. View

Basilius J, Young M, Michaelis T, Hobbs R, Jenkins G, Hartnett M . Structural Abnormalities of the Inner Macula in Incontinentia Pigmenti. JAMA Ophthalmol. 2015; 133(9):1067-72. PMC: 4710467. DOI: 10.1001/jamaophthalmol.2015.1700. View

10.

Lepore D, Molle F, Pagliara M, Baldascino A, Angora C, Sammartino M . Atlas of fluorescein angiographic findings in eyes undergoing laser for retinopathy of prematurity. Ophthalmology. 2010; 118(1):168-75. DOI: 10.1016/j.ophtha.2010.04.021. View

11.

Campbell J, Nudleman E, Yang J, Tan O, Paul Chan R, Chiang M . Handheld Optical Coherence Tomography Angiography and Ultra-Wide-Field Optical Coherence Tomography in Retinopathy of Prematurity. JAMA Ophthalmol. 2017; 135(9):977-981. PMC: 6583755. DOI: 10.1001/jamaophthalmol.2017.2481. View

12.

Shoughy S, Fernando Arevalo J, Kozak I . Update on wide- and ultra-widefield retinal imaging. Indian J Ophthalmol. 2015; 63(7):575-81. PMC: 4652247. DOI: 10.4103/0301-4738.167122. View

13.

Rabiolo A, Parravano M, Querques L, Cicinelli M, Carnevali A, Sacconi R . Ultra-wide-field fluorescein angiography in diabetic retinopathy: a narrative review. Clin Ophthalmol. 2017; 11:803-807. PMC: 5415004. DOI: 10.2147/OPTH.S133637. View

14.

Lepore D, Quinn G, Molle F, Orazi L, Baldascino A, Ji M . Follow-up to Age 4 Years of Treatment of Type 1 Retinopathy of Prematurity Intravitreal Bevacizumab Injection versus Laser: Fluorescein Angiographic Findings. Ophthalmology. 2017; 125(2):218-226. DOI: 10.1016/j.ophtha.2017.08.005. View

15.

Martinez-Castellanos M, Velez-Montoya R, Price K, Henaine-Berra A, Garcia-Aguirre G, Morales-Canton V . Vascular changes on fluorescein angiography of premature infants with low risk of retinopathy of prematurity after high oxygen exposure. Int J Retina Vitreous. 2017; 3:2. PMC: 5238517. DOI: 10.1186/s40942-016-0055-6. View

16.

Witmer M, Parlitsis G, Patel S, Kiss S . Comparison of ultra-widefield fluorescein angiography with the Heidelberg Spectralis(®) noncontact ultra-widefield module versus the Optos(®) Optomap(®). Clin Ophthalmol. 2013; 7:389-94. PMC: 3583407. DOI: 10.2147/OPTH.S41731. View

17.

Pomerantzeff O . Equator-plus camera. Invest Ophthalmol. 1975; 14(5):401-6. View

18.

Sun L, Li G, Miller T, Salorio C, Byrne M, Bellinger D . Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood. JAMA. 2016; 315(21):2312-20. PMC: 5316422. DOI: 10.1001/jama.2016.6967. View

19.

Bonnay G, Nguyen F, Meunier I, Ducasse A, Hamel C, Arndt C . [Screening for retinal detachment using wide-field retinal imaging]. J Fr Ophtalmol. 2011; 34(7):482-5. DOI: 10.1016/j.jfo.2011.02.012. View

20.

Spaide R . Peripheral areas of nonperfusion in treated central retinal vein occlusion as imaged by wide-field fluorescein angiography. Retina. 2011; 31(5):829-37. DOI: 10.1097/IAE.0b013e31820c841e. View