Exposure to Arsenic Alters the Microbiome of Larval Zebrafish

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2018 Jul 7

PMID 29977230

Citations 21

Authors

Dylan Dahan

Brooke A Jude

Regina Lamendella

Felicia Keesing

Gabriel G Perron

Affiliations

Soon will be listed here.

Abstract

Exposure to environmental toxins such as heavy metals can perturb the development and stability of microbial communities associated with human or animal hosts. Widespread arsenic contamination in rivers and riparian habitats therefore presents environmental and health concerns for populations living near sources of contamination. To investigate how arsenic affects host microbiomes, we sequenced and characterized the microbiomes of twenty larval zebrafish exposed to three concentrations of arsenic that are found in contaminated water-low (10 ppb), medium (50 ppb), and high (100 ppb) for 20 days. We found that even a small concentration of arsenic changed the overall microbial composition, structure and diversity of microbial communities, causing dysbiosis in developing larval zebrafish microbiota. In addition, we found that a high concentration of arsenic also increased the abundance of a class 1 integron, an integrase-dependent system facilitating the horizontal transfer of genes conferring resistance to heavy metals and antibiotics.

Citing Articles

Toxic Metals Impact Gut Microbiota and Metabolic Risk in Five African-Origin Populations.

Jorgensen J, Choo-Kang C, Wang L, Issa L, Gilbert J, Ecklu-Mensah G medRxiv. 2024; .

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Arsenic Impairs Wound Healing Processes in Dermal Fibroblasts and Mice.

Dresler S, Pinto B, Salanga M, Propper C, Berry S, Kellar R Int J Mol Sci. 2024; 25(4).

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Assessing the role of the gut microbiome at the interface between environmental chemical exposures and human health: Current knowledge and challenges.

Campana A, Laue H, Shen Y, Shrubsole M, Baccarelli A Environ Pollut. 2022; 315:120380.

PMID: 36220576 PMC: 10239610. DOI: 10.1016/j.envpol.2022.120380.

Bacteria communities and water quality parameters in riverine water and sediments near wastewater discharges.

de Santana C, Spealman P, Azulai D, Reid M, Dueker M, Perron G Sci Data. 2022; 9(1):578.

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Point-of-use carbon-block drinking water filters change gut microbiome of larval zebrafish.

Wu C, Connell M, Zarb A, Akemann C, Morgan S, McElmurry S Environ Microbiol Rep. 2022; 14(4):655-663.

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