Apical and Basal Matrix Remodeling Control Epithelial Morphogenesis

Overview

Journal Dev Cell

Publisher Cell Press

Specialties Cell Biology
Reproductive Medicine

Date 2018 Jul 6

PMID 29974861

Citations 41

Authors

Maria-Del-Carmen Diaz-de-la-Loza

Robert P Ray

Poulami S Ganguly

Silvanus Alt

John R Davis

Andreas Hoppe

Nic Tapon

Guillaume Salbreux

Barry J Thompson

Affiliations

Soon will be listed here.

Abstract

Epithelial tissues can elongate in two dimensions by polarized cell intercalation, oriented cell division, or cell shape change, owing to local or global actomyosin contractile forces acting in the plane of the tissue. In addition, epithelia can undergo morphogenetic change in three dimensions. We show that elongation of the wings and legs of Drosophila involves a columnar-to-cuboidal cell shape change that reduces cell height and expands cell width. Remodeling of the apical extracellular matrix by the Stubble protease and basal matrix by MMP1/2 proteases induces wing and leg elongation. Matrix remodeling does not occur in the haltere, a limb that fails to elongate. Limb elongation is made anisotropic by planar polarized Myosin-II, which drives convergent extension along the proximal-distal axis. Subsequently, Myosin-II relocalizes to lateral membranes to accelerate columnar-to-cuboidal transition and isotropic tissue expansion. Thus, matrix remodeling induces dynamic changes in actomyosin contractility to drive epithelial morphogenesis in three dimensions.

Citing Articles

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Singh A, Thale S, Leibner T, Lamparter L, Ricker A, Nusse H Nat Commun. 2024; 15(1):3198.

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