Comparison of the University of Pittsburgh Staging System and the Eighth Edition of the American Joint Committee on Cancer TNM Classification for the Prognostic Evaluation of External Auditory Canal Cancer

Overview

Journal Int J Clin Oncol

Specialty Oncology

Date 2018 Jul 6

PMID 29974295

Citations 15

Authors

Shinya Morita

Takatsugu Mizumachi

Yuji Nakamaru

Tomohiro Sakashita

Satoshi Kano

Kimiko Hoshino

Atsushi Fukuda

Keishi Fujiwara

Akihiro Homma

Affiliations

Soon will be listed here.

Abstract

Background: The purpose was to compare survival differences between patients with external auditory canal (EAC) cancer treated according to the University of Pittsburgh modified TNM staging system and those treated in accordance with the 8th edition of the American Joint Committee on Cancer (AJCC) staging manual on the TNM staging system for cutaneous cancers of the head and neck.

Methods: We performed a retrospective, single-institution review of 60 patients with EAC cancer treated with curative intent between September 2002 and March 2018. Survival outcomes were measured on the basis of the two staging systems.

Results: The C-index values for the overall survival (OS) rate revealed that the University of Pittsburgh staging system had higher prognostic accuracy than the 8th edition of the AJCC staging system. Univariable and multivariable analysis showed that T classification according to the University of Pittsburgh staging system was an independent predictor of the OS rate (hazard ratio 5.25; 95% confidence interval 1.38-24.9; P = 0.015). Meanwhile, the AJCC staging system could not differentiate T2 from T3-4 cancers.

Conclusion: The University of Pittsburgh staging system for patients with EAC cancer is a valuable tool for use in clinical decision-making and predicting survival outcome.

Citing Articles

The international expert consensus on management of external auditory canal carcinoma.

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Clinical outcome and prognostic factors in adenoid cystic carcinoma of the external auditory canal: proposal for a refined T-stage classification system.

Lee J, Cho Y Eur Arch Otorhinolaryngol. 2023; 280(8):3625-3633.

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Surgical Strategy for Squamous Cell Carcinoma of the External Auditory Canal: Management of Locally Advanced Cases with Skull Base Involvement.

Goto S, Nishio N, Iwami K, Yoshida T, Maruo T, Mukoyama N J Neurol Surg B Skull Base. 2023; 84(1):69-78.

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