Variation in Human T Lymphotropic Virus III (HTLV-III) Antibodies in Homosexual Men: Decline Before Onset of Illness Related to Acquired Immune Deficiency Syndrome (AIDS)

Overview

Journal Br Med J (Clin Res Ed)

Specialty General Medicine

Date 1985 Oct 12

PMID 2996691

Citations 24

Authors

R J Biggar

M Melbye

P Ebbesen

S Alexander

J O Nielsen

P Sarin

V Faber

Affiliations

Soon will be listed here.

Abstract

Western blot analysis was used to document the development and changes in human T lymphotropic virus III (HTLV-III) antibody among Danish homosexual men followed longitudinally over three years. Reactivity against p15, p24, and p55 appeared earliest. After seroconversion the antibody concentration fluctuated, but in one instance a steady decline in banding intensity was seen during the 18 months before onset of the acquired immune deficiency syndrome (AIDS) and throughout the remaining eight months of his life.

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References

Melbye M, Biggar R, Ebbesen P, Sarngadharan M, Weiss S, Gallo R . Seroepidemiology of HTLV-III antibody in Danish homosexual men: prevalence, transmission, and disease outcome. Br Med J (Clin Res Ed). 1984; 289(6445):573-5. PMC: 1442841. DOI: 10.1136/bmj.289.6445.573. View

Schupbach J, Haller O, Vogt M, Luthy R, Joller H, Oelz O . Antibodies to HTLV-III in Swiss patients with AIDS and pre-AIDS and in groups at risk for AIDS. N Engl J Med. 1985; 312(5):265-70. DOI: 10.1056/NEJM198501313120502. View

Weiss S, Goedert J, Sarngadharan M, Bodner A, Gallo R, Blattner W . Screening test for HTLV-III (AIDS agent) antibodies. Specificity, sensitivity, and applications. JAMA. 1985; 253(2):221-5. View

Moskowitz L, HENSLEY G, Chan J, Gregorios J, Conley F . The neuropathology of acquired immune deficiency syndrome. Arch Pathol Lab Med. 1984; 108(11):867-72. View