Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes

Overview

Journal Chem Eng J

Publisher Elsevier

Date 2018 Jul 3

PMID 29962899

Citations 12

Authors

Hideyuki Wada

Hoon Hyun

Kai Bao

Jeong Heon Lee

Georges El Fakhri

Yongdoo Choi

Hak Soo Choi

Affiliations

Soon will be listed here.

Abstract

Lymphadenectomy is a prerequisite for most malignancies to define the precise staging of cancer, as well as resect the possible metastases completely. While it improves prognosis, lymphadenectomy often causes postoperative edema or bleeding because of unclear surgical margins. In this study, we synthesized near-infrared (NIR) fluorescent nanoprobes with conjugating various mannose moieties on the surface to target macrophages in the lymph node. Armed with these NIR nanoprobes, we demonstrated the feasibility of intraoperative pan lymph nodes (PLN) mapping and real-time optical imaging under the NIR fluorescence imaging system. We found that even single mannose-conjugated ZW800-1 showed specific uptake in lymph nodes within 4 h, and multiple mannose-employed polyrotaxanes highlighted PLN efficiently with low background signals in major organs. This technology can help surgeons perform lymphadenectomy with ease and safety by identifying all regional lymph nodes proficiently after a single intravenous injection of NIR nanoprobes.

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