Image-guided Tumor Surgery: The Emerging Role of Nanotechnology

Overview

Journal Wiley Interdiscip Rev Nanomed Nanobiotechnol

Specialty Biotechnology

Date 2020 Mar 13

PMID 32162485

Citations 20

Authors

Nicholas E Wojtynek

Aaron M Mohs

Affiliations

Soon will be listed here.

Abstract

Surgical resection is a mainstay treatment for solid tumors. Yet, methods to distinguish malignant from healthy tissue are primarily limited to tactile and visual cues as well as the surgeon's experience. As a result, there is a possibility that a positive surgical margin (PSM) or the presence of residual tumor left behind after resection may occur. It is well-documented that PSMs can negatively impact treatment outcomes and survival, as well as pose an economic burden. Therefore, surgical tumor imaging techniques have emerged as a promising method to decrease PSM rates. Nanoparticles (NPs) have unique characteristics to serve as optical contrast agents during image-guided surgery (IGS). Recently, there has been tremendous growth in the volume and types of NPs used for IGS, including clinical trials. Herein, we describe the most recent contributions of nanotechnology for surgical tumor identification. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery Diagnostic Tools > in vivo Nanodiagnostics and Imaging.

Citing Articles

A Raman topography imaging method toward assisting surgical tumor resection.

Czaja A, Jiang A, Blanco M, Eremina O, Zavaleta C Npj Imaging. 2025; 2(1).

PMID: 40051976 PMC: 11884652. DOI: 10.1038/s44303-024-00006-6.

Application of nanotechnology in the treatment of hepatocellular carcinoma.

Cai L, Du Y, Xiong H, Zheng H Front Pharmacol. 2024; 15:1438819.

PMID: 39679376 PMC: 11637861. DOI: 10.3389/fphar.2024.1438819.

Nanotechnology in healthcare, and its safety and environmental risks.

Ma X, Tian Y, Yang R, Wang H, Allahou L, Chang J J Nanobiotechnology. 2024; 22(1):715.

PMID: 39548502 PMC: 11566612. DOI: 10.1186/s12951-024-02901-x.

Polymersomes as Innovative, Stimuli-Responsive Platforms for Cancer Therapy.

Negut I, Bita B Pharmaceutics. 2024; 16(4).

PMID: 38675124 PMC: 11053450. DOI: 10.3390/pharmaceutics16040463.

Knowledge mapping of application of image-guided surgery in prostate cancer: a bibliometric analysis (2013-2023).

Zeng N, Sun J, Liu C, Xu J, An Y, Xu M Int J Surg. 2024; 110(5):2992-3007.

PMID: 38445538 PMC: 11093506. DOI: 10.1097/JS9.0000000000001232.

References

Koblinski J, Ahram M, Sloane B . Unraveling the role of proteases in cancer. Clin Chim Acta. 2000; 291(2):113-35. DOI: 10.1016/s0009-8981(99)00224-7. View

Bernhoft R . Cadmium toxicity and treatment. ScientificWorldJournal. 2013; 2013:394652. PMC: 3686085. DOI: 10.1155/2013/394652. View

Klein K, Stolk P, De Bruin M, Leufkens H, Crommelin D, de Vlieger J . The EU regulatory landscape of non-biological complex drugs (NBCDs) follow-on products: Observations and recommendations. Eur J Pharm Sci. 2019; 133:228-235. DOI: 10.1016/j.ejps.2019.03.029. View

Thawani J, Amirshaghaghi A, Yan L, Stein J, Liu J, Tsourkas A . Photoacoustic-Guided Surgery with Indocyanine Green-Coated Superparamagnetic Iron Oxide Nanoparticle Clusters. Small. 2017; 13(37). PMC: 5884067. DOI: 10.1002/smll.201701300. View

Yaghini E, Turner H, Pilling A, Naasani I, MacRobert A . In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model. Nanomedicine. 2018; 14(8):2644-2655. PMC: 6198065. DOI: 10.1016/j.nano.2018.07.009. View

Wang J, Ma Q, Hu X, Liu H, Zheng W, Chen X . Autofluorescence-Free Targeted Tumor Imaging Based on Luminous Nanoparticles with Composition-Dependent Size and Persistent Luminescence. ACS Nano. 2017; 11(8):8010-8017. DOI: 10.1021/acsnano.7b02643. View

Gao H, Bao P, Dai S, Liu R, Ji S, Zeng S . Far-Red/Near-Infrared Emissive (1,3-Dimethyl)barbituric Acid-Based AIEgens for High-Contrast Detection of Metastatic Tumors in the Lung. Chem Asian J. 2018; 14(6):871-876. DOI: 10.1002/asia.201801660. View

Bu L, Shen B, Cheng Z . Fluorescent imaging of cancerous tissues for targeted surgery. Adv Drug Deliv Rev. 2014; 76:21-38. PMC: 4169718. DOI: 10.1016/j.addr.2014.07.008. View

van der Poel H, Buckle T, Brouwer O, Olmos R, van Leeuwen F . Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer. Eur Urol. 2011; 60(4):826-33. DOI: 10.1016/j.eururo.2011.03.024. View

10.

Mohs A, Mancini M, Singhal S, Provenzale J, Leyland-Jones B, Wang M . Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration. Anal Chem. 2010; 82(21):9058-65. PMC: 3030682. DOI: 10.1021/ac102058k. View

11.

Olson M, Ly Q, Mohs A . Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation. Mol Imaging Biol. 2018; 21(2):200-218. PMC: 6724738. DOI: 10.1007/s11307-018-1239-2. View

12.

Ding F, Zhan Y, Lu X, Sun Y . Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging. Chem Sci. 2018; 9(19):4370-4380. PMC: 5961444. DOI: 10.1039/c8sc01153b. View

13.

Zhao T, Huang G, Li Y, Yang S, Ramezani S, Lin Z . A Transistor-like pH Nanoprobe for Tumour Detection and Image-guided Surgery. Nat Biomed Eng. 2017; 1. PMC: 5617128. DOI: 10.1038/s41551-016-0006. View

14.

Sasaki A, Tsukasaki Y, Komatsuzaki A, Sakata T, Yasuda H, Jin T . Recombinant protein (EGFP-Protein G)-coated PbS quantum dots for in vitro and in vivo dual fluorescence (visible and second-NIR) imaging of breast tumors. Nanoscale. 2015; 7(12):5115-9. DOI: 10.1039/c4nr06480a. View

15.

Stummer W, Pichlmeier U, Meinel T, Wiestler O, Zanella F, Reulen H . Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 2006; 7(5):392-401. DOI: 10.1016/S1470-2045(06)70665-9. View

16.

Miller K, Siegel R, Lin C, Mariotto A, Kramer J, Rowland J . Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016; 66(4):271-89. DOI: 10.3322/caac.21349. View

17.

Bradbury M, Phillips E, Montero P, Cheal S, Stambuk H, Durack J . Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions. Integr Biol (Camb). 2012; 5(1):74-86. PMC: 4428677. DOI: 10.1039/c2ib20174g. View

18.

Weber J, Beard P, Bohndiek S . Contrast agents for molecular photoacoustic imaging. Nat Methods. 2016; 13(8):639-50. DOI: 10.1038/nmeth.3929. View

19.

Jin Y, Li Y, Yang X, Tian J . Neuroblastoma-targeting triangular gadolinium oxide nanoplates for precise excision of cancer. Acta Biomater. 2019; 87:223-234. DOI: 10.1016/j.actbio.2019.01.042. View

20.

Tummers W, Miller S, Teraphongphom N, Gomez A, Steinberg I, Huland D . Intraoperative Pancreatic Cancer Detection using Tumor-Specific Multimodality Molecular Imaging. Ann Surg Oncol. 2018; 25(7):1880-1888. PMC: 5977989. DOI: 10.1245/s10434-018-6453-2. View