Pulse Wave Analyzed Cardiovascular Parameters in Young First Degree Relatives of Type 2 Diabetics- a Cross-sectional Study

Overview

Journal Indian Heart J

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 2018 Jul 3

PMID 29961447

Citations 7

Authors

Jayesh D Solanki

Hemant B Mehta

Chinmay J Shah

Affiliations

Soon will be listed here.

Abstract

Background: First degree relatives (FDR) of type 2 diabetic (T2D) are predisposed for type 2 diabetes mellitus (T2DM) which accelerates cardiovascular aging. Pulse wave analysis (PWA) gives non-invasive measurement of central hemodynamics like central blood pressure (cBP), cardiac output (CO), stroke work (SW) and vascular stiffness like pulse wave velocity (PWV) and augmentation index at heart rate 75 (AIx@75).

Objective: To study PWA derived cardiovascular parameters in FDRs of T2D as compared to controls.

Materials And Methods: We enrolled 117 FDRs of T2D and 117 matched controls for a cross-sectional study. We performed PWA using Mobil-o-Graph (IEM, Germany) by oscillometric method to derive cardiovascular parameters which were compared and correlated for significance. P value less than 0.05 was considered statistically significant.

Results: Gender, age, height, weight, body mass index (BMI), physical activity were comparable between groups. FDRs of T2D had significantly higher blood pressure (brachial-systolic 125 vs 118, diastolic 80 vs 77, mean 100 vs 96mmHg and central- systolic 113 vs 105, diastolic 82 vs 79, pulse pressure 31 vs 28mmHg), SW (98 vs 90gm/bt), rate pressure product (RPP- 113 vs 107), PWV (5.14 vs 4.89m/s), AIx@75 (30 vs 27) than control. Dependant variables correlated with brachial BP more than age or anthropometric variables. Result did not differ by maternal or paternal inheritance in case group.

Conclusions: Young, sedentary, non-obese FDRs of T2D have adverse cardiovascular profile which is suggested to worsen before or with onset of T2DM and definitely need attention for life style modification as primary prevention.

Citing Articles

Correlation between Measures of Obesity and Vascular Ageing in Type 2 Diabetics of Rural Regions of West India with Low Prevailing Obesity: A Pulse Wave Analysis Based Cross-Sectional Study.

Solanki J, Vohra A, Shah C, Hirani C, Senta V, Rudani D Niger Med J. 2024; 64(4):448-460.

PMID: 38952885 PMC: 11214705. DOI: 10.60787/NMJ-64-4-205.

Assessment of Arterial Stiffness, Brachial Haemodynamics, and Central Haemodynamics in Diabetic Hypertensives: A Pulse Wave Analysis-Based Case-Control Study from an Urban Area of West India.

Solanki J, Panjwani S, Patel R, Bhatt D, Kakadia P, Shah C Pulse (Basel). 2022; 9(3-4):89-98.

PMID: 35083175 PMC: 8739359. DOI: 10.1159/000519357.

Impact of diabetic retinopathy on pulse wave analysis-derived arterial stiffness and hemodynamic parameters: A cross-sectional study from Gujarat, India.

Solanki J, Kakadia P, Mehta H, Kakadia J, Shah C Indian J Ophthalmol. 2021; 69(11):3250-3254.

PMID: 34708782 PMC: 8725125. DOI: 10.4103/ijo.IJO_3529_20.

Association of brachial and central hemodynamic parameters to eGFR and proteinuria in Gujarati diabetics with mild-to-moderate nephropathy.

Solanki J, Patel R, Hadiyel I, Mehta H, Munshi H, Kakadiya P J Family Med Prim Care. 2019; 8(9):2965-2970.

PMID: 31681676 PMC: 6820418. DOI: 10.4103/jfmpc.jfmpc_493_19.

Central hemodynamics and arterial stiffness by oscillometric pulse-wave analysis in treated Gujarati euglycemic hypertensives: A case-control study.

Solanki J, Mehta H, Panjwani S, Munshi H, Shah C J Family Med Prim Care. 2019; 8(6):2047-2054.

PMID: 31334178 PMC: 6618187. DOI: 10.4103/jfmpc.jfmpc_233_19.

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