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Basis of DATP Inhibition of RNRs

Overview
Journal J Biol Chem
Specialty Biochemistry
Date 2018 Jul 1
PMID 29959279
Citations 5
Authors
Brandon L Greene
Daniel G Nocera
JoAnne Stubbe
Affiliations
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Abstract

Ribonucleotide reductases (RNRs) are essential enzymes producing deoxynucleotide (dNTP) building blocks for DNA replication and repair and regulating dNTP pools important for fidelity of these processes. A new study reveals that the class Ia RNR is regulated by dATP via stabilization of an inactive α4β4 quaternary structure, slowing formation of the active α2β2 structure. The results support the importance of the regulatory α4β4 complex providing insight in design of experiments to understand RNR regulation .

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