Anti-apoptotic Treatment in Mouse Models of Age-related Hearing Loss

Overview

Journal J Otol

Date 2018 Jun 26

PMID 29937804

Citations 1

Authors

Fengchan Han

Oumei Wang

Quanxiang Cai

Affiliations

Soon will be listed here.

Abstract

Age-related hearing loss (AHL), or presbycusis, is the most common neurodegenerative disorder and top communication deficit of the aged population. Genetic predisposition is one of the major factors in the development of AHL. Generally, AHL is associated with an age-dependent loss of sensory hair cells, spiral ganglion neurons and stria vascularis cells in the inner ear. Although the mechanisms leading to genetic hearing loss are not completely understood, caspase-family proteases function as important signals in the inner ear pathology. It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL. Here, we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.

Citing Articles

Mitochondrial Damage and Necroptosis in Aging Cochlea.

Lyu A, Kim T, Park S, Shin S, Jeong S, Yu Y Int J Mol Sci. 2020; 21(7).

PMID: 32260310 PMC: 7177801. DOI: 10.3390/ijms21072505.

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