Large-scale Analysis Demonstrates Familial Testicular Cancer to Have Polygenic Aetiology
Authors
Affiliations
Patient Summary: To date, it has been unclear whether familial clusters of testicular germ cell tumour (TGCT) arise due to genetics or shared environmental or lifestyle factors. We present large-scale genetic analyses comparing 236 familial TGCT cases, 3931 isolated TGCT cases, and 12 368 controls. We show that familial TGCT is caused, at least in part, by presence of a higher dose of the same common genetic variants that cause susceptibility to TGCT in general.
Kuzbari Z, Rowlands C, Wade I, Garrett A, Loveday C, Choi S Eur Urol Open Sci. 2025; 73:51-59.
PMID: 40034715 PMC: 11875187. DOI: 10.1016/j.euros.2025.01.015.
Hemminki K, Hemminki O, Koskinen A, Hemminki A, Forsti A Hered Cancer Clin Pract. 2025; 23(1):9.
PMID: 40016794 PMC: 11866814. DOI: 10.1186/s13053-024-00303-6.
The experience of fertility concerns in patients with testicular cancer: a qualitative study.
Hu Y, Fu X, Jiang X, Jiang M, Zheng X, Lu H Support Care Cancer. 2024; 32(8):529.
PMID: 39028382 PMC: 11271369. DOI: 10.1007/s00520-024-08720-y.
An update on the genetic predisposition of testicular germ cell tumors.
Islam R, Hansen A, Liesen A, Schorle H Transl Androl Urol. 2024; 13(3):476-478.
PMID: 38590959 PMC: 10999021. DOI: 10.21037/tau-23-560.
Further Association of Germline Loss-of-Function Variants with Testicular Germ Cell Tumors.
Kirchner K, Seidel C, Paulsen F, Sievers B, Bokemeyer C, Lessel D J Clin Med. 2023; 12(22).
PMID: 38002677 PMC: 10672725. DOI: 10.3390/jcm12227065.