Towards a Circuit-level Understanding of Hippocampal CA1 Dysfunction in Alzheimer's Disease Across Anatomical Axes

Overview

Journal J Alzheimers Dis Parkinsonism

Date 2018 Jun 22

PMID 29928558

Citations 28

Authors

Arjun V Masurkar

Affiliations

Soon will be listed here.

Abstract

The hippocampus has been a primary region of study with regards to synaptic and functional changes in Alzheimer’s disease (AD) due to its involvement in early stages, specifically area CA1. However, most work in this area has treated CA1 as a homogeneous structure comprised of uniform neural circuits. Yet, there is a plethora of evidence that CA1 varies in its structure and function across anatomical axes. Here I review the heterogeneity of the functional and circuit architecture of hippocampal area CA1 across three primary anatomical axes. I also summarize evidence that AD differentially affects these subregions, as well as hypotheses as to why this may occur.

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