Oxidative and Endoplasmic Reticulum Stress in Respiratory Disease

Overview

Journal Clin Transl Immunology

Specialty Allergy & Immunology

Date 2018 Jun 22

PMID 29928501

Citations 32

Authors

Alice C-H Chen

Lucy Burr

Michael A McGuckin

Affiliations

Soon will be listed here.

Abstract

Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.

Citing Articles

Green tea extract reduces viral proliferation and ROS production during Feline Herpesvirus type-1 (FHV-1) infection.

Longobardi C, Damiano S, Ferrara G, Esposito R, Montagnaro S, Florio S BMC Vet Res. 2024; 20(1):374.

PMID: 39175036 PMC: 11340149. DOI: 10.1186/s12917-024-04227-0.

The Effects of Endoplasmic Reticulum Stress via Intratracheal Instillation of Water-Soluble Acrylic Acid Polymer on the Lungs of Rats.

Morimoto T, Izumi H, Tomonaga T, Nishida C, Kawai N, Higashi Y Int J Mol Sci. 2024; 25(7).

PMID: 38612383 PMC: 11011863. DOI: 10.3390/ijms25073573.

Oxidative stress in the eye and its role in the pathophysiology of ocular diseases.

Bohm E, Buonfiglio F, Voigt A, Bachmann P, Safi T, Pfeiffer N Redox Biol. 2023; 68:102967.

PMID: 38006824 PMC: 10701459. DOI: 10.1016/j.redox.2023.102967.

Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling.

Li C, Zhang H, Mo J, Zuo J, Ye L Arch Toxicol. 2023; 98(1):207-221.

PMID: 37955688 PMC: 10761489. DOI: 10.1007/s00204-023-03626-w.

Immunomodulatory and Antioxidant Drugs in Glaucoma Treatment.

Buonfiglio F, Pfeiffer N, Gericke A Pharmaceuticals (Basel). 2023; 16(9).

PMID: 37765001 PMC: 10535738. DOI: 10.3390/ph16091193.

References

Thomson E, Brennan S, Senthilmohan R, Gangell C, Chapman A, Sly P . Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis. Free Radic Biol Med. 2010; 49(9):1354-60. DOI: 10.1016/j.freeradbiomed.2010.07.010. View

Neveu W, Allard J, Dienz O, Wargo M, Ciliberto G, Whittaker L . IL-6 is required for airway mucus production induced by inhaled fungal allergens. J Immunol. 2009; 183(3):1732-8. PMC: 2929571. DOI: 10.4049/jimmunol.0802923. View

Marciniak S, Ordonez A, Dickens J, Chambers J, Patel V, Dominicus C . New Concepts in Alpha-1 Antitrypsin Deficiency Disease Mechanisms. Ann Am Thorac Soc. 2016; 13 Suppl 4:S289-96. DOI: 10.1513/AnnalsATS.201506-358KV. View

Kesimer M, Ford A, Ceppe A, Radicioni G, Cao R, Davis C . Airway Mucin Concentration as a Marker of Chronic Bronchitis. N Engl J Med. 2017; 377(10):911-922. PMC: 5706541. DOI: 10.1056/NEJMoa1701632. View

Federti E, Matte A, Ghigo A, Andolfo I, James C, Siciliano A . Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension. Free Radic Biol Med. 2017; 112:376-386. DOI: 10.1016/j.freeradbiomed.2017.08.004. View

Zhou J, Perelman J, Kolosov V, Zhou X . Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2. Mol Cell Biochem. 2013; 377(1-2):75-85. DOI: 10.1007/s11010-013-1572-3. View

Hasnain S, Borg D, Harcourt B, Tong H, Sheng Y, Ng C . Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nat Med. 2014; 20(12):1417-26. DOI: 10.1038/nm.3705. View

Hunninghake G, Hatabu H, Okajima Y, Gao W, Dupuis J, Latourelle J . MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013; 368(23):2192-200. PMC: 3747636. DOI: 10.1056/NEJMoa1216076. View

Maitra M, Wang Y, Gerard R, Mendelson C, Garcia C . Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. J Biol Chem. 2010; 285(29):22103-13. PMC: 2903395. DOI: 10.1074/jbc.M110.121467. View

10.

Song J, Kang C, Yoo M, Kim S, Yoon H, Kim Y . Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways. Respir Res. 2007; 8:28. PMC: 1847818. DOI: 10.1186/1465-9921-8-28. View

11.

Kettle A, Chan T, Osberg I, Senthilmohan R, Chapman A, Mocatta T . Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis. Am J Respir Crit Care Med. 2004; 170(12):1317-23. DOI: 10.1164/rccm.200311-1516OC. View

12.

Kenche H, Ye Z, Vedagiri K, Richards D, Gao X, Tew K . Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase. J Biol Chem. 2016; 291(9):4763-78. PMC: 4813498. DOI: 10.1074/jbc.M115.712331. View

13.

Ayaub E, Kolb P, Mohammed-Ali Z, Tat V, Murphy J, Bellaye P . GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. J Pathol. 2016; 239(4):411-25. DOI: 10.1002/path.4738. View

14.

Dickerhof N, Pearson J, Hoskin T, Berry L, Turner R, Sly P . Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency. Free Radic Biol Med. 2017; 113:236-243. DOI: 10.1016/j.freeradbiomed.2017.09.028. View

15.

Ribeiro C, Paradiso A, Carew M, Shears S, Boucher R . Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia. J Biol Chem. 2005; 280(11):10202-9. DOI: 10.1074/jbc.M410617200. View

16.

Smith R, Wolfgang M, Lory S . An adenylate cyclase-controlled signaling network regulates Pseudomonas aeruginosa virulence in a mouse model of acute pneumonia. Infect Immun. 2004; 72(3):1677-84. PMC: 356001. DOI: 10.1128/IAI.72.3.1677-1684.2004. View

17.

Lawson W, Crossno P, Polosukhin V, Roldan J, Cheng D, Lane K . Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol. 2008; 294(6):L1119-26. DOI: 10.1152/ajplung.00382.2007. View

18.

Teng R, Jing X, Michalkiewicz T, Afolayan A, Wu T, Konduri G . Attenuation of endoplasmic reticulum stress by caffeine ameliorates hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2017; 312(5):L586-L598. PMC: 5451596. DOI: 10.1152/ajplung.00405.2016. View

19.

Taylor S, Rogers G, Chen A, Burr L, McGuckin M, Serisier D . Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis. Ann Am Thorac Soc. 2015; 12(5):701-7. DOI: 10.1513/AnnalsATS.201411-513OC. View

20.

Rivas A, Vidal R, Hetz C . Targeting the unfolded protein response for disease intervention. Expert Opin Ther Targets. 2015; 19(9):1203-18. DOI: 10.1517/14728222.2015.1053869. View