Zinc Finger Protein 521 Regulates Early Hematopoiesis Through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 2018 Jun 20

PMID 29915154

Citations 6

Authors

Courtney J Fleenor

Tessa Arends

Hong Lei

Josefine Ahsberg

Kazuki Okuyama

Jacob Kuruvilla

Susana Cristobal

Jennifer L Rabe

Ahwan Pandey

Thomas Danhorn

Desiree Straign

Joaquin M Espinosa

Soren Warming

Eric M Pietras

Mikael Sigvardsson

James R Hagman

Affiliations

Soon will be listed here.

Abstract

Zinc finger protein 521 (ZFP521), a DNA-binding protein containing 30 Krüppel-like zinc fingers, has been implicated in the differentiation of multiple cell types, including hematopoietic stem and progenitor cells (HSPC) and B lymphocytes. Here, we report a novel role for ZFP521 in regulating the earliest stages of hematopoiesis and lymphoid cell development via a cell-extrinsic mechanism. Mice with inactivated genes () possess reduced frequencies and numbers of hematopoietic stem and progenitor cells, common lymphoid progenitors, and B and T cell precursors. Notably, ZFP521 deficiency changes bone marrow microenvironment cytokine levels and gene expression within resident HSPC, consistent with a skewing of hematopoiesis away from lymphopoiesis. These results advance our understanding of ZFP521's role in normal hematopoiesis, justifying further research to assess its potential as a target for cancer therapies.

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