Location of the Trans-activating Region on the Genome of Human T-cell Lymphotropic Virus Type III

Overview

Journal Science

Specialty Science

Date 1985 Jul 5

PMID 2990041

Citations 224

Authors

J Sodroski

R Patarca

C Rosen

F Wong-Staal

W Haseltine

Affiliations

Soon will be listed here.

Abstract

The retrovirus involved in acquired immune deficiency syndrome (HTLV-III/LAV) contains a region that is necessary for stimulation of gene expression directed by the viral long terminal repeat. This region is located between nucleotides 5365 and 5607, immediately 5' to the envelope gene. A doubly-spliced message containing this region could encode an 86-amino acid protein with structural features similar to those of nucleic acid-binding proteins.

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