Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics

Overview

Journal Front Oncol

Specialty Oncology

Date 2018 Jun 13

PMID 29892572

Citations 40

Authors

Shao Thing Teoh

Martin P Ogrodzinski

Christina Ross

Kent W Hunter

Sophia Y Lunt

Affiliations

Soon will be listed here.

Abstract

Metastatic breast cancer is currently incurable. It has recently emerged that different metabolic pathways support metastatic breast cancer. To further uncover metabolic pathways enabling breast cancer metastasis, we investigated metabolic differences in mouse tumors of differing metastatic propensities using mass spectrometry-based metabolomics. We found that sialic acid metabolism is upregulated in highly metastatic breast tumors. Knocking out a key gene in sialic acid metabolism, , inhibits synthesis of the activated form of sialic acid, cytidine monophosphate-sialic acid and decreases the formation of lung metastases . Thus, the sialic acid pathway may be a new target against metastatic breast cancer.

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