Neuroimaging Investigations of Dorsal Stream Processing and Effects of Stimulus Synchrony in Schizophrenia

Overview

Journal Psychiatry Res Neuroimaging

Publisher Elsevier

Specialties Neurology
Psychiatry
Radiology

Date 2018 Jun 10

PMID 29884441

Citations 3

Authors

Lori Sanfratello

Cheryl Aine

Julia Stephen

Affiliations

Soon will be listed here.

Abstract

Impairments in auditory and visual processing are common in schizophrenia (SP). In the unisensory realm visual deficits are primarily noted for the dorsal visual stream. In addition, insensitivity to timing offsets between stimuli are widely reported for SP. The aim of the present study was to test at the physiological level differences in dorsal/ventral stream visual processing and timing sensitivity between SP and healthy controls (HC) using MEG and a simple auditory/visual task utilizing a variety of multisensory conditions. The paradigm included all combinations of synchronous/asynchronous and central/peripheral stimuli, yielding 4 task conditions. Both HC and SP groups showed activation in parietal areas (dorsal visual stream) during all multisensory conditions, with parietal areas showing decreased activation for SP relative to HC, and a significantly delayed peak of activation for SP in intraparietal sulcus (IPS). We also observed a differential effect of stimulus synchrony on HC and SP parietal response. Furthermore, a (negative) correlation was found between SP positive symptoms and activity in IPS. Taken together, our results provide evidence of impairment of the dorsal visual stream in SP during a multisensory task, along with an altered response to timing offsets between presented multisensory stimuli.

Citing Articles

Reliability of the Test of Visual Perceptual Skills-4th Edition for people with schizophrenia.

Lee S, Chiu E PLoS One. 2025; 20(3):e0318148.

PMID: 40036226 PMC: 11878909. DOI: 10.1371/journal.pone.0318148.

Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning in schizophrenia.

Sehatpour P, Kreither J, Lopez-Calderon J, Shastry A, De Baun H, Martinez A Transl Psychiatry. 2023; 13(1):360.

PMID: 37993420 PMC: 10665365. DOI: 10.1038/s41398-023-02656-3.

A systematic review of the neural correlates of multisensory integration in schizophrenia.

Grohn C, Norgren E, Eriksson L Schizophr Res Cogn. 2021; 27:100219.

PMID: 34660211 PMC: 8502765. DOI: 10.1016/j.scog.2021.100219.

Prospects for Future Methodological Development and Application of Magnetoencephalography Devices in Psychiatry.

Hironaga N, Takei Y, Mitsudo T, Kimura T, Hirano Y Front Psychiatry. 2020; 11:863.

PMID: 32973591 PMC: 7472776. DOI: 10.3389/fpsyt.2020.00863.

References

Stephen J, Ranken D, Aine C . Frequency-following and connectivity of different visual areas in response to contrast-reversal stimulation. Brain Topogr. 2006; 18(4):257-72. DOI: 10.1007/s10548-006-0004-z. View

Donohue S, Roberts K, Grent-t-Jong T, Woldorff M . The cross-modal spread of attention reveals differential constraints for the temporal and spatial linking of visual and auditory stimulus events. J Neurosci. 2011; 31(22):7982-90. PMC: 3224815. DOI: 10.1523/JNEUROSCI.5298-10.2011. View

Rauschecker J . Parallel processing in the auditory cortex of primates. Audiol Neurootol. 1998; 3(2-3):86-103. DOI: 10.1159/000013784. View

Zundorf I, Lewald J, Karnath H . Testing the dual-pathway model for auditory processing in human cortex. Neuroimage. 2015; 124(Pt A):672-681. DOI: 10.1016/j.neuroimage.2015.09.026. View

Dale A, Liu A, Fischl B, Buckner R, Belliveau J, Lewine J . Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution imaging of cortical activity. Neuron. 2000; 26(1):55-67. DOI: 10.1016/s0896-6273(00)81138-1. View

Williams T, Nuechterlein K, Subotnik K, Yee C . Distinct neural generators of sensory gating in schizophrenia. Psychophysiology. 2010; 48(4):470-8. PMC: 2994969. DOI: 10.1111/j.1469-8986.2010.01119.x. View

Andersen R . Multimodal integration for the representation of space in the posterior parietal cortex. Philos Trans R Soc Lond B Biol Sci. 1997; 352(1360):1421-8. PMC: 1692052. DOI: 10.1098/rstb.1997.0128. View

Gramfort A, Luessi M, Larson E, Engemann D, Strohmeier D, Brodbeck C . MNE software for processing MEG and EEG data. Neuroimage. 2013; 86:446-60. PMC: 3930851. DOI: 10.1016/j.neuroimage.2013.10.027. View

Butler P, Silverstein S, Dakin S . Visual perception and its impairment in schizophrenia. Biol Psychiatry. 2008; 64(1):40-7. PMC: 2435292. DOI: 10.1016/j.biopsych.2008.03.023. View

10.

Nuechterlein K . Reaction time and attention in schizophrenia: a critical evaluation of the data and theories. Schizophr Bull. 1977; 3(3):373-428. DOI: 10.1093/schbul/3.3.373. View

11.

Poppel E . Lost in time: a historical frame, elementary processing units and the 3-second window. Acta Neurobiol Exp (Wars). 2004; 64(3):295-301. DOI: 10.55782/ane-2004-1514. View

12.

Wible C, Preus A, Hashimoto R . A Cognitive Neuroscience View of Schizophrenic Symptoms: Abnormal Activation of a System for Social Perception and Communication. Brain Imaging Behav. 2009; 3(1):85-110. PMC: 2757313. DOI: 10.1007/s11682-008-9052-1. View

13.

Benevento L, Fallon J, Davis B, Rezak M . Auditory--visual interaction in single cells in the cortex of the superior temporal sulcus and the orbital frontal cortex of the macaque monkey. Exp Neurol. 1977; 57(3):849-72. DOI: 10.1016/0014-4886(77)90112-1. View

14.

Livingstone M, Hubel D . Psychophysical evidence for separate channels for the perception of form, color, movement, and depth. J Neurosci. 1987; 7(11):3416-68. PMC: 6569044. View

15.

Kaposvari P, Csete G, Bognar A, Csibri P, Toth E, Szabo N . Audio-visual integration through the parallel visual pathways. Brain Res. 2015; 1624:71-77. DOI: 10.1016/j.brainres.2015.06.036. View

16.

Stephen J, Knoefel J, Adair J, Hart B, Aine C . Aging-related changes in auditory and visual integration measured with MEG. Neurosci Lett. 2010; 484(1):76-80. PMC: 2948493. DOI: 10.1016/j.neulet.2010.08.023. View

17.

Stone D, Coffman B, Bustillo J, Aine C, Stephen J . Multisensory stimuli elicit altered oscillatory brain responses at gamma frequencies in patients with schizophrenia. Front Hum Neurosci. 2014; 8:788. PMC: 4220133. DOI: 10.3389/fnhum.2014.00788. View

18.

Anderson J, Ferguson M, Lopez-Larson M, Yurgelun-Todd D . Topographic maps of multisensory attention. Proc Natl Acad Sci U S A. 2010; 107(46):20110-4. PMC: 2993335. DOI: 10.1073/pnas.1011616107. View

19.

Chen Y, Shore D, Lewis T, Maurer D . The development of the perception of audiovisual simultaneity. J Exp Child Psychol. 2016; 146:17-33. DOI: 10.1016/j.jecp.2016.01.010. View

20.

Mosher J, Leahy R, Lewis P . EEG and MEG: forward solutions for inverse methods. IEEE Trans Biomed Eng. 1999; 46(3):245-59. DOI: 10.1109/10.748978. View