Maternal and Early-life Vitamin D Deficiency Enhances Allergic Reaction in an Ovalbumin-sensitized BALB/c Mouse Model

Overview

Journal Food Nutr Res

Specialty Nutritional Sciences

Date 2018 Jun 9

PMID 29881333

Citations 11

Authors

Jiang Wu

Yan Zhong

Xiuhua Shen

Kefeng Yang

Wei Cai

Affiliations

Soon will be listed here.

Abstract

Background: Recent studies have shown that vitamin D deficiency may contribute to the high prevalence of food allergy but the underlying mechanisms are far from clear.

Objective: The present study was designed to investigate the effect of maternal and early-life vitamin D deficiency in the development of food allergy.

Design: BALB/c mice were treated with ovalbumin (OVA) to trigger allergic reactions, under vitamin D-deficient (by maternal and early-life feeding of vitamin D deprived chow diet) or vitamin D-sufficient conditions.

Results: Increased occurrence and severity of allergic diarrhea as well as decreased rectal temperature were observed after OVA sensitization. For vitamin D deficiency groups, OVA-specific IgE and IL-4 levels were significantly increased, while IFN-γ levels were unchanged. Vitamin D deficiency also attenuated the structure of small intestinal villi and decreased the expression of the tight junction protein between adjacent epithelial cells and the percentages of CD4CD25Foxp3Treg cell in spleen and mesenteric lymph nodes.

Conclusions: Maternal and early-life vitamin D deficiency have notable influence on the susceptibility to food allergy, which may relate with the reduced population of Treg cell and the dysfunction of intestinal epithelial barrier.

Citing Articles

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Serum vitamin D status in a cohort of infants with food protein‑induced gastrointestinal disease.

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Zhou Y, Qiu Y, Bao W, Han L, Xue Y, Zhang Y Front Immunol. 2023; 14:1107031.

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Murdaca G, Allegra A, Tonacci A, Musolino C, Ricciardi L, Gangemi S Biomedicines. 2022; 10(8).

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