Detection of Felis Catus Papillomavirus Type 3 and 4 DNA from Squamous Cell Carcinoma Cases of Cats in Japan

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2018 Jun 8

PMID 29877210

Citations 17

Authors

Nanako Yamashita-Kawanishi

Ryoma Sawanobori

Kosuke Matsumiya

Akiko Uema

James K Chambers

Kazuyuki Uchida

Hidekatsu Shimakura

Masano Tsuzuki

Chia-Yu Chang

Hui-Wen Chang

Takeshi Haga

Affiliations

Soon will be listed here.

Abstract

Association of felis catus papillomaviruses (FcaPVs) with feline squamous cell carcinoma (SCC) has been reported worldwide, while there is limited information about FcaPVs in Asia. In this study, 21 feline SCC biopsy samples from cats in Japan were analyzed by PCR with PV consensus primers and type-specific primers for FcaPV type 2 (FcaPV-2), FcaPV-3 and FcaPV-4 designed in this study. Sequence analysis revealed that one sample was FcaPV-3, and two were FcaPV-4. In both FcaPV-4 positive samples, 334th tryptophan in L1 ORF was deleted compared with the reference sequence. Moreover, immunohistochemistry showed that p16 protein was positive in both FcaPV-4 detected samples. This study would contribute to the molecular epidemiological and pathological understanding of FcaPV in Japan.

Citing Articles

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